Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5364597 | 0.88 | SMN1; SMN2 (0.47) | SMN1; SMN2CYP2C19TDP1ALDH1A1KDM4E | |
| SCHEMBL5366185 | 0.86 | POLB (0.64) | SMN1; SMN2CYP2C19TDP1ALDH1A1POLB | |
| SCHEMBL6583576 | 0.86 | POLB (0.64) | SMN1; SMN2CYP2C19TDP1ALDH1A1POLB | |
| SCHEMBL5374449 | 0.85 | HSD17B10 (0.64) | SMN1; SMN2CYP2C19TDP1ALDH1A1KDM4E | |
| SCHEMBL5367391 | 0.83 | CHRM1 (0.48) | POLBCHRM1HPGD | |
| SCHEMBL9442953 | 0.83 | ALDH1A1 (0.55) | SMN1; SMN2ALDH1A1KDM4ERAB9AGAA | |
| SCHEMBL9442957 | 0.83 | ALDH1A1 (0.55) | SMN1; SMN2ALDH1A1KDM4ERAB9AGAA | |
| SCHEMBL10447907 | 0.81 | TSHR (0.61) | CYP2C19TDP1GAAKMT2ACHRM1 | |
| SCHEMBL9442942 | 0.81 | TSHR (0.57) | SMN1; SMN2CYP2C19TDP1ALDH1A1GAA | |
| SCHEMBL9442990 | 0.81 | TSHR (0.61) | CYP2C19TDP1GAAKMT2ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |