Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5364603 | 0.88 | TPSAB1 (0.44) | OPRK1OPRD1 | |
| SCHEMBL5366189 | 0.86 | HDAC8 (0.59) | POLBOPRK1OPRD1 | |
| SCHEMBL5374453 | 0.85 | HSD17B10 (0.64) | CHRM1HPGDCHRM2CHRM3POLB | |
| SCHEMBL5367387 | 0.83 | SMN1; SMN2 (0.58) | CHRM1HPGDPOLB | |
| SCHEMBL9442942 | 0.81 | TSHR (0.57) | CHRM1HPGDHSD17B10 | |
| SCHEMBL9442990 | 0.81 | TSHR (0.61) | CHRM1HPGDHSD17B10 | |
| SCHEMBL10447907 | 0.81 | TSHR (0.61) | CHRM1HPGDHSD17B10 | |
| SCHEMBL7328737 | 0.79 | TSHR (0.64) | CHRM1HPGDHSD17B10ALOX15 | |
| SCHEMBL7328742 | 0.79 | TSHR (0.64) | CHRM1HPGDHSD17B10ALOX15 | |
| SCHEMBL4924905 | 0.78 | HDAC3 (0.68) | OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |