Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.69 |
| ▸ | FAAH | O00519 | 14/20 | 0.59 |
| ▸ | CES1 | P23141 | 10/20 | 0.59 |
| ▸ | CES2 | O00748 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | PLG | P00747 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9338632 | 0.88 | HDAC6 (0.64) | HDAC6FAAHCES1CES2MEN1 | |
| SCHEMBL7393724 | 0.81 | FAAH (0.64) | HDAC6FAAHCES1CES2MEN1 | |
| SCHEMBL23465657 | 0.80 | PAOX (0.52) | HDAC6FAAHCES1CES2MEN1 | |
| SCHEMBL3775993 | 0.78 | — | — | |
| SCHEMBL10697629 | 0.76 | FAAH (0.64) | HDAC6FAAHCES1CES2MEN1 | |
| SCHEMBL7371814 | 0.76 | FAAH (0.64) | HDAC6FAAHCES1CES2MEN1 | |
| SCHEMBL2222667 | 0.76 | FAAH (0.64) | HDAC6FAAHCES1CES2MEN1 | |
| SCHEMBL10388810 | 0.76 | FAAH (0.64) | HDAC6FAAHCES1CES2MEN1 | |
| Trifluoroacetic Acid SCHEMBL28761253 | 0.76 | LMNA (0.54) | HDAC6MEN1KMT2ACYP1A2ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL1930024 | 0.76 | LMNA (0.54) | HDAC6MEN1KMT2ACYP1A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7223833-B1 | Peptide nucleic acid conjugates | ISIS PHARMACEUTICALS, INC. (US) | 2007-05-29 | — | — | US | disclosed |
| EP-0804456-B1 | PEPTIDE NUCLEIC ACID CONJUGATES | ISIS PHARMACEUTICALS INC (US) | 2002-08-21 | — | — | EP | disclosed |
| EP-0804456-A4 | PEPTIDE NUCLEIC ACID CONJUGATES | ISIS PHARMACEUTICALS INC (US) | 1999-05-19 | — | — | EP | disclosed |
| EP-0804456-A1 | PEPTIDE NUCLEIC ACID CONJUGATES | ISIS PHARMACEUTICALS, INC. (US) | 1997-11-05 | — | — | EP | disclosed |
| WO-1996011205-A9 | PEPTIDE NUCLEIC ACID CONJUGATES | — | 1996-05-30 | — | — | WO | disclosed |
| WO-1996011205-A1 | PEPTIDE NUCLEIC ACID CONJUGATES | ISIS PHARMACEUTICALS, INC. (US) | 1996-04-18 | — | — | WO | disclosed |