Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 13/20 | 0.53 |
| ▸ | HTR1B | P28222 | 10/20 | 0.53 |
| ▸ | CCR2 | P41597 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5328392 | 0.87 | OPRM1 (0.46) | HTR1DHTR1BCCR2KMT2AOPRM1 | |
| SCHEMBL1121919 | 0.87 | HTR1D (0.68) | HTR1DHTR1BCCR2KDM4EBRD4 | |
| SCHEMBL5457655 | 0.86 | HTR1D (0.57) | HTR1DHTR1BCCR2KMT2AOPRM1 | |
| SCHEMBL5323484 | 0.86 | KMT2A (0.61) | CCR2KMT2AKDM4EBRD4ALDH1A1 | |
| SCHEMBL5456752 | 0.84 | HTR1D (0.62) | HTR1DHTR1BCCR2CHRM2DRD2 | |
| SCHEMBL5466905 | 0.83 | CCR2 (0.55) | HTR1DHTR1BCCR2CHRM2DRD2 | |
| SCHEMBL5326741 | 0.77 | KMT2A (0.60) | CCR2KMT2AKDM4EBRD4ALDH1A1 | |
| SCHEMBL5353861 | 0.77 | OPRL1 (0.55) | CCR2OPRM1OPRK1OPRL1 | |
| SCHEMBL7489311 | 0.77 | HTR1D (0.74) | HTR1DHTR1BOPRM1OPRK1OPRL1 | |
| SCHEMBL5326744 | 0.76 | KMT2A (0.61) | CCR2KMT2AKDM4EBRD4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007130712-A1 | SUBSTITUTED DIPIPERIDINE AS CCR2 ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | JANSSEN PHARMACEUTICA, NV (BE) | 2007-11-15 | — | — | WO | claimed |