Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 8/20 | 0.57 |
| ▸ | HTR1B | P28222 | 6/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CCR2 | P41597 | 2/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5367805 | 0.86 | HTR1D (0.53) | HTR1DHTR1BKMT2ACCR2OPRM1 | |
| SCHEMBL5326779 | 0.85 | KMT2A (0.65) | KMT2ACYP2D6ADRB2HTR2C | |
| SCHEMBL5353061 | 0.82 | HTR1D (0.64) | HTR1DHTR1BCHRM2DRD2 | |
| SCHEMBL5328392 | 0.80 | OPRM1 (0.46) | HTR1DHTR1BKMT2ACCR2OPRM1 | |
| SCHEMBL7482397 | 0.79 | HTR1D (0.68) | HTR1DHTR1BCCR2CYP1A2CYP3A4 | |
| SCHEMBL7489311 | 0.77 | HTR1D (0.74) | HTR1DHTR1BOPRM1OPRK1OPRL1 | |
| SCHEMBL427406 | 0.73 | HTR1D (1.00) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5457649 | 0.73 | KMT2A (0.64) | KMT2ACYP2D6DRD2 | |
| Hydrochloric Acid SCHEMBL27483631 | 0.72 | HTR1D (0.97) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL7485776 | 0.72 | HTR1D (0.97) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070197590-A1 | SUBSTITUTED DIPIPERIDINE CCR2 ANTAGONISTS | JANSSEN PHARMACEUTCA N.V. (BE) | 2007-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197590-A1 | SUBSTITUTED DIPIPERIDINE CCR2 ANTAGONISTS | CCR2, CCR1, CCR5 | HTR1D 804/4885HTR1B 680/4885KMT2A 2990/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.