Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | MAT2A | P31153 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27682181 | 0.87 | SIGMAR1 (0.35) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4772575 | 0.87 | PTGS2 (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4774921 | 0.85 | PDE4B (0.34) | MAT2A | |
| SCHEMBL5116230 | 0.85 | MAPT (0.35) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL27662703 | 0.84 | PRKAA2 (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4772589 | 0.84 | MAPT (0.33) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL27662807 | 0.84 | DPP4 (0.34) | SIGMAR1 | |
| SCHEMBL4778031 | 0.83 | PSEN1 (0.34) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL27662580 | 0.83 | MAPT (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4776223 | 0.83 | MAPT (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763528-A1 | PYRAZOLOPYRIDINE DERIVATIVES | Astellas Pharma Inc. (JP) | 2007-03-21 | — | — | EP | disclosed |
| WO-2006004188-A1 | PYRAZOLOPYRIDINE DERIVATIVES | ASTELLAS PHARMA INC. (JP) | 2006-01-12 | — | — | WO | disclosed |