Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ME2 | P23368 | 1/20 | 0.56 |
| ▸ | ME1 | P48163 | 1/20 | 0.56 |
| ▸ | ME3 | Q16798 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5366718 | 0.89 | SMN1; SMN2 (0.56) | MEN1KMT2AKDM4EPKMALDH1A1 | |
| SCHEMBL5370693 | 0.89 | KMT2A (0.57) | MEN1KMT2AKDM4EPKMALDH1A1 | |
| SCHEMBL5362882 | 0.89 | MMP13 (0.56) | KMT2AKDM4EPKMALDH1A1POLB | |
| SCHEMBL5370951 | 0.89 | HPGD (0.57) | MEN1KMT2AKDM4EPKMALDH1A1 | |
| SCHEMBL5366075 | 0.85 | MEN1 (0.56) | MEN1KMT2AKDM4EPKMALDH1A1 | |
| SCHEMBL5521812 | 0.81 | HDAC3 (0.51) | MEN1KMT2ACHRM4HDAC3HDAC4 | |
| SCHEMBL5523321 | 0.81 | HDAC3 (0.51) | MEN1KMT2ACHRM4HDAC3HDAC4 | |
| SCHEMBL5521806 | 0.81 | HDAC3 (0.51) | MEN1KMT2ACHRM4HDAC3HDAC4 | |
| SCHEMBL5362915 | 0.81 | HDAC6 (0.60) | ME2ME1ME3KDM4EPKM | |
| SCHEMBL6536256 | 0.81 | KDM4E (0.55) | MEN1KMT2AKDM4EPKMCHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |