Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | PLG | P00747 | 1/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.46 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.46 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5370693 | 0.89 | KMT2A (0.57) | ALDH1A1SMN1; SMN2KMT2APOLBFKBP1A | |
| SCHEMBL5366718 | 0.89 | SMN1; SMN2 (0.56) | ALDH1A1SMN1; SMN2KMT2APOLBHTT | |
| SCHEMBL5367904 | 0.89 | ME2 (0.56) | ALDH1A1SMN1; SMN2KMT2APOLBUSP2 | |
| SCHEMBL5370951 | 0.85 | HPGD (0.57) | ALDH1A1SMN1; SMN2KMT2APOLBHTT | |
| SCHEMBL5368197 | 0.80 | TPSAB1 (0.72) | MMP13KDM4EPKMF2PLG | |
| SCHEMBL5366075 | 0.79 | MEN1 (0.56) | ALDH1A1KMT2APOLBHTTHPGD | |
| SCHEMBL19708998 | 0.78 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2KMT2APOLBHTT | |
| SCHEMBL14425676 | 0.77 | HTT (0.46) | MMP13ALDH1A1SMN1; SMN2KMT2APOLB | |
| SCHEMBL5359305 | 0.77 | KCNH2 (0.73) | SMN1; SMN2KMT2A | |
| SCHEMBL6536256 | 0.76 | KDM4E (0.55) | KMT2AKDM4EPKMF2PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |