Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 14/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5376744 | 0.92 | ALDH1A1 (0.38) | TRPM8HCRTR2KDM4EALDH1A1PKM | |
| SCHEMBL5371938 | 0.90 | TRPM8 (0.39) | TRPM8HCRTR2SERPINE1 | |
| SCHEMBL5368411 | 0.89 | RXRA (0.39) | TRPM8ALDH1A1SERPINE1 | |
| SCHEMBL5378792 | 0.87 | TRPM8 (0.43) | TRPM8HCRTR2KDM4EALDH1A1PKM | |
| SCHEMBL5391241 | 0.86 | ALDH1A1 (0.35) | TRPM8HCRTR2ALDH1A1 | |
| SCHEMBL5382107 | 0.84 | SMN1; SMN2 (0.35) | TRPM8HCRTR2KDM4EALDH1A1PKM | |
| SCHEMBL5376782 | 0.83 | GAA (0.36) | ALDH1A1PKM | |
| SCHEMBL5378588 | 0.82 | TRPM8 (0.38) | TRPM8HCRTR2KDM4EALDH1A1PKM | |
| SCHEMBL5373225 | 0.80 | TP53 (0.36) | HCRTR2ALDH1A1 | |
| SCHEMBL5373830 | 0.78 | RXRA (0.40) | TRPM8ALDH1A1CNR2SERPINE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7262318-B2 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER, INC. (US) | 2007-08-28 | — | — | US | disclosed |
| US-20060258723-A1 | Substituted Heteroaryl- and Phenylsulfamoyl Compounds | PFIZER INC | 2006-11-16 | — | — | US | disclosed |
| US-20050228015-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER INC | 2005-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050228015-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PPARA, PPARG, PPARD | TRPM8 4317/4885HCRTR2 3933/4885KDM4E 3834/4885 |
| US-20060258723-A1 | Substituted Heteroaryl- and Phenylsulfamoyl Compounds | PPARG, PPARA, PPARD | TRPM8 4175/4885HCRTR2 3863/4885KDM4E 3815/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.