Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.69 |
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.62 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.60 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.57 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.57 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.57 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.55 |
| ▸ | NAAA | Q02083 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | FAAH | O00519 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | ME2 | P23368 | 1/20 | 0.53 |
| ▸ | ME1 | P48163 | 1/20 | 0.53 |
| ▸ | ME3 | Q16798 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17551531 | 0.92 | SIGMAR1 (0.59) | POLBNPC1TDP1GRIN2BFKBP1A | |
| SCHEMBL8540623 | 0.87 | POLB (0.71) | POLBNPC1TDP1GRIN2BFKBP1A | |
| SCHEMBL18435561 | 0.87 | POLB (0.71) | POLBNPC1TDP1GRIN2BFKBP1A | |
| SCHEMBL19982162 | 0.86 | POLB (0.66) | POLBNPC1TDP1GRIN2BFKBP1A | |
| SCHEMBL5368499 | 0.86 | KDM1A (0.54) | POLBNPC1TDP1GRIN2BHPGD | |
| SCHEMBL24043594 | 0.85 | POLB (0.69) | POLBNPC1TDP1GRIN2BFKBP1A | |
| SCHEMBL8540059 | 0.85 | POLB (0.69) | POLBNPC1TDP1GRIN2BFKBP1A | |
| SCHEMBL16591625 | 0.85 | POLB (0.69) | POLBNPC1TDP1GRIN2BFKBP1A | |
| SCHEMBL4704483 | 0.85 | POLB (0.73) | POLBNPC1TDP1GRIN2BFKBP1A | |
| SCHEMBL6289171 | 0.84 | POLB (0.77) | POLBNPC1TDP1GRIN2BFKBP1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |
| US-20040204341-A1 | Nr2b receptor antagonists for the treatment or prevention of migraines | ALLEN CHRISTOPHER (US) | 2004-10-14 | — | — | US | disclosed |
| US-20030119811-A1 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK SHARP & DOHME CORP. | 2003-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040204341-A1 | Nr2b receptor antagonists for the treatment or prevention of migraines | HTR1B, HTR2B, HTR1A | POLB 3223/4885NPC1 1381/4885TDP1 2328/4885 |
| US-20030119811-A1 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | GRIN1, GRIN2B, GRIN2A | POLB 4217/4885NPC1 1441/4885TDP1 4178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.