Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5369484 | 0.86 | POLB (0.69) | POLBALDH1A1KMT2AMEN1GRIN2B | |
| SCHEMBL14525763 | 0.85 | ALDH1A1 (0.50) | POLBALDH1A1KMT2AMEN1MAPK1 | |
| SCHEMBL23241211 | 0.84 | POLB (0.55) | POLBALDH1A1KMT2AMEN1MAPK1 | |
| SCHEMBL5368494 | 0.83 | KDM4E (0.64) | POLBALDH1A1KMT2AMEN1MAPK1 | |
| SCHEMBL16846602 | 0.82 | POLB (0.76) | POLBALDH1A1KMT2AMEN1MAPK1 | |
| SCHEMBL10195731 | 0.81 | NPC1 (0.70) | POLBALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL11136022 | 0.80 | NPC1 (0.56) | POLBALDH1A1NPC1LMNATDP1 | |
| SCHEMBL8701414 | 0.79 | NPC1 (0.68) | POLBALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL10195733 | 0.78 | KMT2A (0.57) | POLBALDH1A1KMT2AMEN1MAPK1 | |
| SCHEMBL17551531 | 0.78 | SIGMAR1 (0.59) | POLBALDH1A1KMT2AMEN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |