Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 16/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4502247 | 0.81 | MAOA (0.51) | MAOAKCNH2MAOBCYP3A4CYP2D6 | |
| SCHEMBL5956177 | 0.73 | MAOA (0.44) | MAOAGRM2KCNH2MAOBCYP3A4 | |
| SCHEMBL4488687 | 0.71 | MAOA (0.57) | MAOAKCNH2MAOBCYP3A4CYP2D6 | |
| SCHEMBL4898414 | 0.70 | MAOA (0.63) | MAOAKCNH2MAOBCYP3A4CYP2D6 | |
| SCHEMBL4482016 | 0.70 | MAOA (0.57) | MAOAKCNH2MAOBCYP3A4CYP2D6 | |
| SCHEMBL4493652 | 0.69 | MAOA (0.51) | MAOAKCNH2MAOBCYP3A4CYP2D6 | |
| SCHEMBL5658882 | 0.68 | MAOA (0.54) | MAOAKCNH2MAOBCYP3A4 | |
| SCHEMBL2478684 | 0.65 | MAOA (0.49) | MAOAKCNH2MAOBCYP3A4CYP2D6 | |
| SCHEMBL5670931 | 0.64 | MAOA (0.88) | MAOAKCNH2CYP3A4CYP2D6 | |
| SCHEMBL4171617 | 0.64 | MAOA (0.62) | MAOAKCNH2MAOBCYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7192974-B2 | Hydroxymethyl substituted dihydroisoxazole derivatives useful as antibiotic agents | ASTRAZENECA AB (SE) | 2007-03-20 | — | — | US | disclosed |