Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 16/20 | 0.62 |
| ▸ | MAOB | P27338 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5955468 | 1.00 | MAOA (0.62) | MAOAMAOBCYP3A4CYP2D6KCNH2 | |
| SCHEMBL4898414 | 0.85 | MAOA (0.63) | MAOAMAOBCYP3A4CYP2D6KCNH2 | |
| SCHEMBL4482016 | 0.84 | MAOA (0.57) | MAOAMAOBCYP3A4CYP2D6KCNH2 | |
| SCHEMBL6510342 | 0.83 | MAOA (0.72) | MAOAMAOBCYP3A4CYP2D6KCNH2 | |
| SCHEMBL21999062 | 0.83 | MAOA (0.72) | MAOAMAOBCYP3A4CYP2D6KCNH2 | |
| SCHEMBL11983302 | 0.83 | MAOA (0.73) | MAOAMAOBCYP3A4CYP2D6KCNH2 | |
| SCHEMBL4502247 | 0.83 | MAOA (0.51) | MAOAMAOBCYP3A4CYP2D6KCNH2 | |
| SCHEMBL4493652 | 0.83 | MAOA (0.51) | MAOAMAOBCYP3A4CYP2D6KCNH2 | |
| SCHEMBL3328501 | 0.82 | CYP3A4 (0.79) | MAOAMAOBCYP3A4CYP2D6KCNH2 | |
| SCHEMBL3328495 | 0.82 | CYP3A4 (0.79) | MAOAMAOBCYP3A4CYP2D6KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9771345-B2 | Coferons and methods of making and using them | CORNELL UNIVERSITY (US) | 2017-09-26 | — | — | US | disclosed |
| US-9771345-B2 | Coferons and methods of making and using them | CORNELL UNIVERSITY (US) | 2017-09-26 | — | — | US | disclosed |
| US-9422274-B2 | Oxazolidinone derivatives and composition for preventing or treating hepatitis C containing the same | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2016-08-23 | — | — | US | disclosed |
| US-9422274-B2 | Oxazolidinone derivatives and composition for preventing or treating hepatitis C containing the same | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2016-08-23 | — | — | US | disclosed |
| US-9422274-B2 | Oxazolidinone derivatives and composition for preventing or treating hepatitis C containing the same | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2016-08-23 | — | — | US | disclosed |
| US-9376400-B2 | Process for the synthesis of triazoles | MELINTA THERAPEUTICS, INC. (US) | 2016-06-28 | — | — | US | disclosed |
| US-9376400-B2 | Process for the synthesis of triazoles | MELINTA THERAPEUTICS, INC. (US) | 2016-06-28 | — | — | US | disclosed |
| US-20150158827-A1 | Process for the Synthesis of Triazoles | MELINTA SUBSIDIARY CORP. | 2015-06-11 | — | — | US | disclosed |
| US-20150158827-A1 | Process for the Synthesis of Triazoles | MELINTA SUBSIDIARY CORP. | 2015-06-11 | — | — | US | disclosed |
| US-20150148386-A1 | Oxazolidinone derivatives and composition for preventing or treating Hepatitis C containing the same | POSTECH ACADEMY-INDUSTRY FOUNDATION (KR) | 2015-05-28 | — | — | US | disclosed |
| US-20060116400-A1 | Oxazolidinone and/or isoxazoline derivatives as antibacterial agents | ASTRAZENECA AB (SE) | 2006-06-01 | — | — | US | disclosed |
| US-20060116386-A1 | Oxazolidinones as antibacterial agents | ASTRAZENECA AB (SE) | 2006-06-01 | — | — | US | disclosed |
| US-20060058314-A1 | Oxazolidinone derivatives and their use as antibacterial agents | ASTRAZENECA AB (SE) | 2006-03-16 | — | — | US | disclosed |
| WO-2005116023-A1 | 3- {4- (PYRIDIN-3-YL) PHENYL} -5- (1H-1, 2, 3-TRIAZOL-1-YLMETHYL) -1, 3-OXAZOLIDIN-2-ONES AS ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | WO | disclosed |
| WO-2005116017-A1 | PROCESS FOR THE PREPARATION OF ARYL SUBSTITUTED OXAZOLIDINONES AS INTERMEDIATES FOR ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | WO | disclosed |
| WO-2005116024-A1 | 3- (4- (2-DIHYDROISOXAZOL-3-YLPYRIDIN-5-YL) PHENYL) -5-TRIAZOL-1-YLMETHYLOXAZOLIDIN-2-ONE DERIVAIVES AS MAO INHIBITORS FOR THE TREATMENT OF BACTERIAL INFECTIONS | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | WO | disclosed |
| WO-2005116022-A1 | 3- `4- {6-SUBSTITUTED ALKANOYL) PYRIDIN-3-YL} -3-PHENYL! -5- (1H-1, 2, 3-TRIAZOL-1-YLMETHYL) -1, 3-OXAZOLIDIN-2-ONES AS ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | WO | disclosed |
| WO-2005116021-A1 | 3-[4-(6-{4,5-DIHYDROISOXAZOL-3-YL}PYRIDIN-3-YL)-3-PHENYL]-5-(1H-1,2,3-TRIAZOL-1-YLMETHYL)-1,3-OXAZOLIDIN-2-ONES AS ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | WO | disclosed |
| EP-1599471-A1 | HYDROXYMETHYL SUBSTITUTED DIHYDROISOXAZOLE DERIVATIVES USEFUL AS ANTIBIOTIC AGENTS | Astrazeneca AB (SE) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004078753-A1 | HYDROXYMETHYL SUBSTITUTED DIHYDROISOXAZOLE DERIVATIVES USEFUL AS ANTIBIOTIC AGENTS | ASTRAZENECA AB (SE) | 2004-09-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060116386-A1 | Oxazolidinones as antibacterial agents | MRPL21, MRPS23, DPP3 | MAOA 279/4885MAOB 120/4885CYP3A4 1089/4885 |
| US-20060058314-A1 | Oxazolidinone derivatives and their use as antibacterial agents | NR0B1, NR0B2, CYP8B1 | MAOA 519/4885MAOB 331/4885CYP3A4 662/4885 |
| US-20060116400-A1 | Oxazolidinone and/or isoxazoline derivatives as antibacterial agents | NR0B2, NR0B1, HRH2 | MAOA 293/4885MAOB 168/4885CYP3A4 372/4885 |
| US-20150148386-A1 | Oxazolidinone derivatives and composition for preventing or treating Hepatitis C containing the same | CYP7A1, CYP7B1, CYP3A7 | MAOA 2474/4885MAOB 1597/4885CYP3A4 75/4885 |
| US-20150158827-A1 | Process for the Synthesis of Triazoles | PROKR1, SI, IL33 | MAOA 1726/4885MAOB 1344/4885CYP3A4 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.