Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5374061 | 0.81 | GAA (0.45) | HTR7MEN1KMT2AHDAC6SLC6A2 | |
| SCHEMBL7073760 | 0.79 | SIGMAR1 (0.47) | HTR7SIGMAR1HDAC6MAPT | |
| SCHEMBL5371611 | 0.78 | HDAC6 (0.44) | HTR7HDAC6SLC6A2SLC6A4 | |
| SCHEMBL5732388 | 0.70 | GAA (0.49) | MEN1KMT2AHDAC6ALDH1A1MAPT | |
| SCHEMBL5383002 | 0.70 | SLC6A2 (0.51) | HDAC6SLC6A2SLC6A4 | |
| SCHEMBL5365880 | 0.68 | SLC6A2 (0.41) | HDAC6SLC6A2SLC6A4 | |
| SCHEMBL27016353 | 0.68 | PRMT6 (0.82) | SIGMAR1PRMT6SLC6A2 | |
| SCHEMBL5377672 | 0.68 | HDAC6 (0.49) | MEN1KMT2AHDAC6ALDH1A1MAPT | |
| SCHEMBL5375990 | 0.67 | GAA (0.51) | KMT2AHDAC6ALDH1A1KDM4E | |
| SCHEMBL5368021 | 0.67 | GAA (0.48) | HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6589954-B1 | Indoles, benzimidazoles and benztriazoles which are substituted at the 5 or 6 position with a substituent comprising an aromatic moiety linked through a piperazine ring to said indole, benzimidazole or benztriazole are useful | SCIOS, INC. | 2003-07-08 | — | — | US | disclosed |