Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 14/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5322795 | 0.84 | ALDH1A1 (0.64) | MAPTALDH1A1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL28038246 | 0.82 | ALDH1A1 (0.69) | MAPTALDH1A1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL27703769 | 0.81 | MAPT (0.49) | MAPTALDH1A1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL3538126 | 0.81 | ALDH1A1 (0.68) | MAPTALDH1A1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL22094803 | 0.81 | ALDH1A1 (0.68) | MAPTALDH1A1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL957198 | 0.80 | MAPT (0.61) | MAPTALDH1A1CYP1A2CYP2C19LMNA | |
| SCHEMBL27646270 | 0.80 | MAPT (0.53) | MAPTALDH1A1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL10359737 | 0.80 | MAPT (0.65) | MAPTALDH1A1L3MBTL1LMNANPSR1 | |
| SCHEMBL16823203 | 0.78 | MAPT (0.48) | MAPTALDH1A1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL3154116 | 0.78 | MAPT (0.64) | MAPTALDH1A1CYP1A2CYP2C19LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856075-A1 | SUBSTITUTED ARYLAMINE COMPOUNDS AND THEIR USE AS 5-HT6 MODULATORS | Epix Delaware, Inc. (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006081332-A1 | SUBSTITUTED ARYLAMINE COMPOUNDS AND THEIR USE AS 5-HT6 MODULATORS | EPIX DELAWARE, INC. (US) | 2006-08-03 | — | — | WO | disclosed |