Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.37 |
| ▸ | KLK1 | P06870 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.36 |
| ▸ | RELA | Q04206 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.36 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.36 |
| ▸ | CPT1A | P50416 | 1/20 | 0.35 |
| ▸ | METAP1 | P53582 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5377258 | 0.93 | ALDH1A1 (0.48) | ALDH1A1FFAR1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL5382597 | 0.92 | ALDH1A1 (0.41) | ALDH1A1FFAR1KLKB1KLK1SMN1; SMN2 | |
| SCHEMBL5385880 | 0.92 | ALDH1A1 (0.46) | ALDH1A1FFAR1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL5380518 | 0.91 | FFAR1 (0.47) | FFAR1CPT1AFFAR4 | |
| SCHEMBL5377358 | 0.89 | TP53 (0.46) | ALDH1A1KLKB1KLK1SMN1; SMN2RAB9A | |
| SCHEMBL5372016 | 0.88 | L3MBTL1 (0.42) | ALDH1A1FFAR1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL5381657 | 0.88 | ALDH1A1 (0.42) | ALDH1A1FFAR1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL5377265 | 0.87 | ALDH1A1 (0.41) | ALDH1A1FFAR1KLKB1SMN1; SMN2RAB9A | |
| SCHEMBL5385582 | 0.86 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2RAB9ANPC1TP53 | |
| SCHEMBL5397102 | 0.85 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2RAB9ANPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7179823-B1 | 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-20 | — | — | US | disclosed |
| EP-1457490-A1 | 5-membered N-heterocyclic compounds with hypoglycemic and hypolipidemic activity | Takeda Chemical Industries, Ltd. (JP) | 2004-09-15 | — | — | EP | disclosed |
| EP-1228067-B1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-07-14 | — | — | EP | disclosed |