Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 2/20 | 0.43 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5385296 | 0.92 | PTGER3 (0.48) | NR1H4PPARGBACE1HDAC8ALOX5 | |
| SCHEMBL5377058 | 0.91 | BACE1 (0.43) | NR1H4L3MBTL1LMNAPPARGBACE1 | |
| SCHEMBL6592132 | 0.87 | PTGER3 (0.51) | BACE1S1PR5ALDH1A1PTGS1PTGS2 | |
| SCHEMBL6592125 | 0.87 | PTGER3 (0.51) | BACE1S1PR5ALDH1A1PTGS1PTGS2 | |
| SCHEMBL5387806 | 0.86 | FFAR1 (0.55) | PPARG | |
| SCHEMBL5397126 | 0.82 | GAA (0.61) | NR1H4L3MBTL1LMNAPTGDR2ALDH1A1 | |
| SCHEMBL5385879 | 0.81 | KMT2A (0.47) | L3MBTL1LMNAPPARGALDH1A1SMN1; SMN2 | |
| SCHEMBL6595111 | 0.80 | PTGER3 (0.61) | BACE1ALDH1A1PTGS1PTGS2ALOX5 | |
| SCHEMBL6595113 | 0.80 | PTGER3 (0.61) | BACE1ALDH1A1PTGS1PTGS2ALOX5 | |
| SCHEMBL5374881 | 0.80 | LTB4R (0.47) | NR1H4L3MBTL1PPARGS1PR5PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7179823-B1 | 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-20 | — | — | US | disclosed |