Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5375510 | 0.93 | HRH3 (0.50) | HRH3MEN1KMT2AKDM4CP4HTM | |
| SCHEMBL5376202 | 0.93 | P4HTM (0.48) | HRH3MEN1KMT2AKDM4CP4HTM | |
| SCHEMBL4658615 | 0.91 | P4HTM (0.50) | HRH3MEN1KMT2AKDM4CP4HTM | |
| SCHEMBL5379438 | 0.90 | LMNA (0.48) | HRH3MEN1KMT2AKDM4CP4HTM | |
| SCHEMBL5392310 | 0.89 | MMP1 (0.47) | HRH3MEN1KMT2AKDM4CP4HTM | |
| SCHEMBL5379659 | 0.89 | EGFR (0.44) | HRH3MEN1KMT2AKDM4CP4HTM | |
| SCHEMBL5381466 | 0.84 | MAPK1 (0.46) | HRH3MEN1KMT2AP4HTMMMP1 | |
| SCHEMBL14400076 | 0.84 | HRH3 (0.44) | HRH3KMT2AKDM4CCYP4F2CYP4A11 | |
| SCHEMBL21840806 | 0.81 | HRH3 (0.60) | HRH3MEN1KMT2AKDM4CMMP2 | |
| SCHEMBL30438225 | 0.81 | HRH3 (0.60) | HRH3MEN1KMT2AKDM4CMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7288545-B2 | Piperazinedione compounds | ANGIORX CORPORATION (TW) | 2007-10-30 | — | — | US | disclosed |
| US-7288545-B2 | Piperazinedione compounds | ANGIORX CORPORATION (TW) | 2007-10-30 | — | — | US | disclosed |
| US-20040132738-A1 | Piperazinedione compounds | ANGIORX CORPORATION (TW) | 2004-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040132738-A1 | Piperazinedione compounds | CBR1, KDR, FLT1 | HRH3 549/4885MEN1 4806/4885KMT2A 2913/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.