Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.45 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5375510 | 0.97 | HRH3 (0.50) | P4HTMHRH3MEN1KMT2AKDM4C | |
| SCHEMBL4658615 | 0.97 | P4HTM (0.50) | P4HTMHRH3MEN1KMT2AKDM4C | |
| SCHEMBL5379438 | 0.94 | LMNA (0.48) | P4HTMHRH3MEN1KMT2AKDM4C | |
| SCHEMBL5374989 | 0.93 | HRH3 (0.44) | P4HTMHRH3MEN1KMT2AKDM4C | |
| SCHEMBL5392310 | 0.93 | MMP1 (0.47) | P4HTMHRH3MEN1KMT2AKDM4C | |
| SCHEMBL5379659 | 0.93 | EGFR (0.44) | P4HTMHRH3MEN1KMT2AKDM4C | |
| SCHEMBL5381466 | 0.91 | MAPK1 (0.46) | P4HTMHRH3MEN1KMT2ATNKS2 | |
| SCHEMBL14400075 | 0.87 | HRH3 (0.50) | HRH3KMT2AKDM4CPPARGL3MBTL1 | |
| SCHEMBL5380505 | 0.86 | HSD17B10 (0.42) | P4HTMHRH3MEN1KMT2AKDM4C | |
| SCHEMBL5374807 | 0.86 | P4HTM (0.41) | P4HTMHRH3MEN1KMT2AKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7288545-B2 | Piperazinedione compounds | ANGIORX CORPORATION (TW) | 2007-10-30 | — | — | US | disclosed |
| US-7288545-B2 | Piperazinedione compounds | ANGIORX CORPORATION (TW) | 2007-10-30 | — | — | US | disclosed |
| US-20040132738-A1 | Piperazinedione compounds | ANGIORX CORPORATION (TW) | 2004-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040132738-A1 | Piperazinedione compounds | CBR1, KDR, FLT1 | P4HTM 1191/4885HRH3 549/4885MEN1 4806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.