Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.55 |
| ▸ | CTSZ | Q9UBR2 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 8/20 | 0.54 |
| ▸ | NPC1 | O15118 | 6/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | NPY1R | P25929 | 1/20 | 0.52 |
| ▸ | NPY2R | P49146 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14408085 | 0.79 | ALDH1A1 (0.61) | HSD11B1ALDH1A1CTSZKDM4ERAB9A | |
| SCHEMBL14408096 | 0.76 | ALDH1A1 (0.52) | ALDH1A1KDM4ERAB9ANPC1CYP1A2 | |
| SCHEMBL22639759 | 0.73 | ALDH1A1 (0.61) | HSD11B1ALDH1A1CTSZKDM4ERAB9A | |
| SCHEMBL653025 | 0.70 | PKM (0.87) | ALDH1A1TSHRATM | |
| SCHEMBL17382809 | 0.70 | NPC1 (0.69) | ALDH1A1CTSZKDM4ERAB9ANPC1 | |
| SCHEMBL14408074 | 0.70 | ALDH1A1 (0.59) | ALDH1A1CTSZKDM4ERAB9ANPC1 | |
| SCHEMBL1535157 | 0.69 | ATM (0.72) | ALDH1A1KDM4ERAB9ANPC1MAPK1 | |
| SCHEMBL4831672 | 0.69 | ATM (0.72) | ALDH1A1KDM4ERAB9ANPC1MAPK1 | |
| SCHEMBL2554034 | 0.68 | TSHR (0.67) | ALDH1A1KDM4ERAB9ANPC1MAPK1 | |
| SCHEMBL627847 | 0.68 | ATM (0.70) | ALDH1A1KDM4ERAB9ANPC1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7271195-B2 | Carbonyl compounds as inhibitors of histone deacetylase for the treatment of disease | KALYPSYS, INC. (US) | 2007-09-18 | — | — | US | disclosed |
| US-7271195-B2 | Carbonyl compounds as inhibitors of histone deacetylase for the treatment of disease | KALYPSYS, INC. (US) | 2007-09-18 | — | — | US | disclosed |
| US-7271195-B2 | Carbonyl compounds as inhibitors of histone deacetylase for the treatment of disease | KALYPSYS, INC. (US) | 2007-09-18 | — | — | US | disclosed |
| EP-1635800-A2 | CARBONYL COMPOUNDS AS INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE | Kalypsys, Inc. (US) | 2006-03-22 | — | — | EP | disclosed |
| US-20050026907-A1 | Carbonyl compounds as inhibitors of histone deacetylase for the treatment of disease | KALYPSYS, INC. (US) | 2005-02-03 | — | — | US | disclosed |
| WO-2004110418-A2 | CARBONYL COMPOUNDS AS INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2004-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026907-A1 | Carbonyl compounds as inhibitors of histone deacetylase for the treatment of disease | HDAC6, HDAC5, HDAC1 | HSD11B1 2629/4885ALDH1A1 208/4885CTSZ 2276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.