Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | GCGR | P47871 | 8/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | GRK2 | P25098 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5386993 | 0.88 | GSK3B (0.48) | GSK3BGCGRMAPK14CDC7 | |
| SCHEMBL5376093 | 0.86 | GSK3B (0.63) | GSK3BMAPK14CDC7 | |
| SCHEMBL5390451 | 0.84 | GSK3B (0.45) | GSK3BGCGRMAPK14CDC7 | |
| SCHEMBL5382412 | 0.83 | CYP3A4 (0.41) | GSK3BGCGRMAPK14ROCK2 | |
| SCHEMBL5381458 | 0.83 | CYP17A1 (0.47) | GSK3BGCGRMAPK14CDC7 | |
| SCHEMBL5382469 | 0.82 | GSK3B (0.49) | GSK3BGCGRCDC7 | |
| SCHEMBL5386907 | 0.82 | GSK3B (0.48) | GSK3BCDC7 | |
| SCHEMBL5376071 | 0.80 | GSK3B (0.49) | GSK3BCDC7 | |
| SCHEMBL5380257 | 0.79 | MAPT (0.49) | GSK3BCDC7 | |
| SCHEMBL5390690 | 0.79 | GSK3B (0.48) | GSK3BMAPK14ROCK2CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115721-B1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEM CORP (JP) | 2003-12-10 | — | — | EP | claimed |
| EP-1115721-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2001-07-18 | — | — | EP | claimed |
| WO-2000018758-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2000-04-06 | — | — | WO | claimed |
| US-7256199-B1 | Pyrimidone derivatives | MITSUBISHI CHEMICAL CORPORATION (JP) | 2007-08-14 | — | — | US | disclosed |
| EP-1115721-B1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEM CORP (JP) | 2003-12-10 | — | — | EP | disclosed |