Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
| ▸ | CDC7 | O00311 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5382412 | 0.86 | CYP3A4 (0.41) | LMNAGSK3BKMT2AL3MBTL1SMN1; SMN2 | |
| SCHEMBL5380263 | 0.85 | GSK3B (0.48) | GSK3BCDC7KMT2APDE10A | |
| SCHEMBL5376093 | 0.81 | GSK3B (0.63) | GSK3BCDC7KMT2ADAOPDE10A | |
| SCHEMBL5380262 | 0.81 | GSK3B (0.70) | MAPTKDM4ELMNAGSK3BCDC7 | |
| SCHEMBL5375203 | 0.79 | GSK3B (0.47) | GSK3BCDC7 | |
| SCHEMBL5383560 | 0.78 | KDM4E (0.44) | MAPTKDM4ELMNAGSK3BCDC7 | |
| SCHEMBL5386907 | 0.77 | GSK3B (0.48) | MAPTLMNAGSK3BCDC7SMN1; SMN2 | |
| SCHEMBL7992854 | 0.76 | GPR84 (0.41) | MAPTCDC7MEN1KMT2AL3MBTL1 | |
| SCHEMBL5386527 | 0.76 | GSK3B (0.53) | GSK3BCDC7PDE10A | |
| SCHEMBL5391617 | 0.75 | KDM4E (0.49) | MAPTKDM4ELMNAGSK3BCDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7256199-B1 | Pyrimidone derivatives | MITSUBISHI CHEMICAL CORPORATION (JP) | 2007-08-14 | — | — | US | disclosed |
| EP-1115721-B1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEM CORP (JP) | 2003-12-10 | — | — | EP | disclosed |
| EP-1115721-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000018758-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2000-04-06 | — | — | WO | disclosed |