Sugi Predict

Sugi Predict / Compounds / SCHEMBL537543

SCHEMBL537543

SCHEMBL537543

CCOC(=O)CC(C#N)C(=O)OCC

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GAA P10253 2/20 0.43
▸ MGAM O43451 1/20 0.43
▸ SI P14410 1/20 0.43
▸ MGAM2 Q2M2H8 1/20 0.43
▸ ALDH1A1 P00352 8/20 0.41
▸ TSHR P16473 3/20 0.41
▸ CYP3A4 P08684 2/20 0.41
▸ ALOX15 P16050 2/20 0.41
▸ TDP1 Q9NUW8 2/20 0.41
▸ HSD17B10 Q99714 2/20 0.40
▸ CHRM1 P11229 1/20 0.40
▸ ADORA1 P30542 1/20 0.40
▸ TRPA1 O75762 1/20 0.40
▸ KMT2A Q03164 3/20 0.37
▸ MEN1 O00255 2/20 0.37
▸ SMN1; SMN2 Q16637 2/20 0.37
▸ CYP2D6 P10635 1/20 0.36
▸ L3MBTL1 Q9Y468 1/20 0.36
▸ HTT P42858 2/20 0.36
▸ LMNA P02545 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23175627 0.89 GAA (0.45) GAAMGAMSIMGAM2ALDH1A1
SCHEMBL28989912 0.86 CYP2D6 (0.38) GAAMGAMSIMGAM2ALDH1A1
SCHEMBL28289194 0.85 ALOX15 (0.40) GAAMGAMSIMGAM2ALDH1A1
SCHEMBL8355327 0.84 ALDH1A1 (0.39) GAAMGAMSIMGAM2ALDH1A1
SCHEMBL1752394 0.84 ALDH1A1 (0.38) GAAMGAMSIMGAM2ALDH1A1
SCHEMBL28989920 0.83 TRPM8 (0.41) GAAMGAMSIMGAM2ALDH1A1
SCHEMBL1441850 0.82 ALDH1A1 (0.37) GAAMGAMSIMGAM2ALDH1A1
SCHEMBL28989957 0.81 ALDH1A1 (0.39) GAAALDH1A1TSHRTDP1HSD17B10
SCHEMBL10902100 0.81 ALDH1A1 (0.42) GAAMGAMSIMGAM2ALDH1A1
SCHEMBL10920266 0.81 ALDH1A1 (0.42) GAAMGAMSIMGAM2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12121880-B2 Catalyst component for olefin polymerization, preparation method thereof, and catalyst including same CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2024-10-22 — — US disclosed
US-20210205787-A1 CATALYST COMPONENT FOR OLEFIN POLYMERIZATION, PREPARATION METHOD THEREOF, AND CATALYST INCLUDING SAME BEIJING RESEARCH INSTITUTE OF CHEMICAL INDUSTRY, CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2021-07-08 — — US disclosed
US-20210205787-A1 CATALYST COMPONENT FOR OLEFIN POLYMERIZATION, PREPARATION METHOD THEREOF, AND CATALYST INCLUDING SAME BEIJING RESEARCH INSTITUTE OF CHEMICAL INDUSTRY, CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2021-07-08 — — US disclosed
EP-3798241-A1 CATALYST COMPONENT FOR OLEFIN POLYMERIZATION, PREPARATION METHOD THEREOF, AND CATALYST INCLUDING SAME China Petroleum & Chemical Corporation (CN) 2021-03-31 — — EP disclosed
CN-109111535-B Catalyst component for olefin polymerization and catalyst thereof 中国石油化工股份有限公司 2021-03-16 — — CN disclosed
CN-109111538-B Catalyst component for olefin polymerization and catalyst thereof 中国石油化工股份有限公司 2021-02-05 — — CN disclosed
CN-110511302-B Catalyst component for olefin polymerization and catalyst thereof 中国石油化工股份有限公司 2020-10-23 — — CN disclosed
CN-110511302-A A kind of catalytic component and its catalyst for olefinic polymerization CHINA PETROLEUM & CHEM CORP 2019-11-29 — — CN disclosed
EP-1767528-B1 PROCESS FOR PRODUCING 5-HYDROXY-4-THIOMETHYLPYRAZOLE COMPOUND IHARA CHEMICAL IND CO (JP) 2014-09-17 — — EP disclosed
WO-2013121017-A1 PROCESS AND EQUIPMENT FOR THE PREPARATION OF HALOCARBOXYLIC ACID ALKYL ESTERS LONZA LTD (CH) 2013-08-22 — — WO disclosed
WO-2007072159-A1 PREPARATION OF GAMMA-AMINO ACIDS HAVING AFFINITY FOR THE ALPHA-2-DELTA PROTEIN PFIZER PRODUCTS INC. (US) 2007-06-28 — — WO disclosed
US-20070141684-A1 Preparation of gamma-amino acids having affinity for the alpha-2-delta protein PFIZER INC 2007-06-21 — — US disclosed
EP-1767528-A1 PROCESS FOR PRODUCING 5-HYDROXY-4-THIOMETHYLPYRAZOLE COMPOUND IHARA CHEMICAL INDUSTRY Co., Ltd. (JP) 2007-03-28 — — EP disclosed
US-5750550-A RESPIRATORY SYSTEM DISORDERS SANOFI (FR) 1998-05-12 — — US disclosed
WO-1997010243-A1 2-(PYRAZOL-5-YL-OXYMETHYL)-1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SANOFI (US) 1997-03-20 — — WO disclosed
EP-0385809-B1 Pesticidal 3-cyano-5-alkoxy-1-arylpyrazoles RHONE POULENC AGROCHIMIE (FR) 1995-07-05 — — EP disclosed
US-5079370-A 1-arylpyrazoles RHONE-POULENC AG COMPANY (US) 1992-01-07 — — US disclosed
US-5047550-A Pesticides RHONE-POULENC AG CO. (US) 1991-09-10 — — US disclosed
EP-0385809-A1 Pesticidal 3-cyano-5-alkoxy-1-arylpyrazoles RHONE-POULENC AGROCHIMIE (FR) 1990-09-05 — — EP disclosed
US-4918085-A INSECTICIDES, NEMATOCIDES, ANTHELMINTICS, AND ANTIPROTOZOA AGENTS RHONE-POULENC AG COMPANY (US) 1990-04-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070141684-A1 Preparation of gamma-amino acids having affinity for the alpha-2-delta protein SCN2A, CACNG2, SCN1A GAA 2831/4885MGAM 4448/4885SI 3573/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.