Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAA2 | P54646 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | MAT2A | P31153 | 9/20 | 0.35 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.31 |
| ▸ | MTOR | P42345 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27662707 | 0.84 | MAT2A (0.38) | ADORA3ADORA2AADORA1MAT2APTGER3 | |
| SCHEMBL27662635 | 0.84 | PRKAA2 (0.36) | PRKAA2ADORA3ADORA2AADORA1MAT2A | |
| SCHEMBL4778910 | 0.83 | ADORA3 (0.35) | ADORA3ADORA2AADORA1MAT2APTGER3 | |
| SCHEMBL4776296 | 0.82 | RXRA (0.35) | ADORA3ADORA2AADORA1MAT2APTGER3 | |
| SCHEMBL4776302 | 0.82 | RXRA (0.35) | ADORA3ADORA2AADORA1MAT2APTGER3 | |
| SCHEMBL4777635 | 0.82 | MAT2A (0.41) | MAT2APTGER3 | |
| SCHEMBL27662703 | 0.80 | PRKAA2 (0.36) | PRKAA2MAT2APDE5APIK3CAMTOR | |
| SCHEMBL27682217 | 0.80 | PRKAA2 (0.36) | PRKAA2MAT2APDE5APIK3CAMTOR | |
| SCHEMBL27682210 | 0.79 | ACVR2A (0.35) | PRKAA2ADORA3ADORA2AADORA1MAT2A | |
| SCHEMBL27662583 | 0.78 | MAT2A (0.35) | PRKAA2ADORA3ADORA2AADORA1MAT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1980927-A | Pyrazolopyridine derivatives | ASTELLAS PHARMA INC (JP) | 2007-06-13 | — | — | CN | disclosed |
| EP-1763528-A1 | PYRAZOLOPYRIDINE DERIVATIVES | Astellas Pharma Inc. (JP) | 2007-03-21 | — | — | EP | disclosed |
| WO-2006004188-A1 | PYRAZOLOPYRIDINE DERIVATIVES | ASTELLAS PHARMA INC. (JP) | 2006-01-12 | — | — | WO | disclosed |