SCHEMBL5376168

SCHEMBL5376168

CC(C)(c1ccccc1)c1ccc2nc(-c3ccccc3C(F)(F)F)oc(=O)c2c1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
C1R P00736 10/20 0.66
PRSS1 P07477 2/20 0.43
CTSG P08311 2/20 0.43
KLK7 P49862 2/20 0.43
KLK14 Q9P0G3 2/20 0.43
KLK5 Q9Y337 2/20 0.43
KMT2A Q03164 2/20 0.41
UTRN P46939 1/20 0.41
PSMB8 P28062 1/20 0.41
F2 P00734 1/20 0.41
PLG P00747 1/20 0.41
KLK1 P06870 1/20 0.41
C1S P09871 1/20 0.41
ATM Q13315 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
NOTUM Q6P988 1/20 0.41
F7 P08709 1/20 0.41
F3 P13726 1/20 0.41
MEN1 O00255 1/20 0.41
CTRC Q99895 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5380224 0.84 NPC1 (0.49) C1RKMT2AL3MBTL1F7F3
SCHEMBL14462682 0.83 F7 (0.45) C1RKMT2AF2F7F3
SCHEMBL5385483 0.82 F7 (0.49) KMT2AUTRNF2NOTUMF7
SCHEMBL5387023 0.82 C1R (0.66) C1RPRSS1CTSGKLK7KLK14
SCHEMBL5382664 0.82 ELANE (0.57) C1RKMT2AF2MEN1
SCHEMBL14462683 0.82 NPC1 (0.55) C1RKMT2AF2L3MBTL1MEN1
SCHEMBL5371767 0.81 C1R (0.69) C1RPRSS1CTSGKLK7KLK14
SCHEMBL11814947 0.80 C1R (1.00) C1RPRSS1KMT2APSMB8F2
SCHEMBL914467 0.77 C1R (0.67) C1RPRSS1KMT2AF2PLG
SCHEMBL14462720 0.76 ELANE (0.59) C1RPRSS1KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7244776-B2 Ultraviolet light absorbers CIBA SPECIALTY CHEMICALS CORPORATION (US) 2007-07-17 US disclosed
US-20070100031-A1 Ultraviolet light absorbers RAVICHANDRAN RAMANATHAN 2007-05-03 US disclosed
US-7173128-B2 Ultraviolet light absorbers CIBA SPECIALTY CHEMICALS CORPORATION (US) 2007-02-06 US disclosed
US-20040192684-A1 Ultraviolet light absorbers CIBA SPECIALTY CHEMICALS CORPORATION 2004-09-30 US disclosed
EP-1430038-A1 ULTRAVIOLET LIGHT ABSORBERS Ciba SC Holding AG (CH) 2004-06-23 EP disclosed
WO-2003016292-A1 ULTRAVIOLET LIGHT ABSORBERS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2003-02-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040192684-A1 Ultraviolet light absorbers UNG, MSH6, MAL2 C1R 3037/4885PRSS1 1902/4885CTSG 3411/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.