SCHEMBL5380224

SCHEMBL5380224

CC(C)(c1ccccc1)c1ccc2nc(-c3ccc(C(F)(F)F)cc3)oc(=O)c2c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 5/20 0.49
RAB9A P51151 5/20 0.49
ALDH1A1 P00352 7/20 0.48
KDM4E B2RXH2 5/20 0.48
XBP1 P17861 1/20 0.48
ELANE P08246 2/20 0.48
MAPT P10636 4/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
LMNA P02545 1/20 0.46
RXFP1 Q9HBX9 1/20 0.46
F7 P08709 1/20 0.46
F3 P13726 1/20 0.46
PTPN2 P17706 2/20 0.44
PTPN1 P18031 2/20 0.44
PTPN5 P54829 2/20 0.44
HPGD P15428 2/20 0.44
TP53 P04637 1/20 0.44
C1R P00736 1/20 0.43
HSPD1 P10809 1/20 0.43
HSPE1 P61604 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14462683 0.94 NPC1 (0.55) NPC1RAB9AALDH1A1KDM4EXBP1
SCHEMBL14462682 0.92 F7 (0.45) NPC1RAB9AALDH1A1KDM4EXBP1
SCHEMBL5382664 0.91 ELANE (0.57) NPC1RAB9AALDH1A1KDM4EXBP1
SCHEMBL5385483 0.91 F7 (0.49) NPC1RAB9AALDH1A1KDM4EELANE
SCHEMBL3452610 0.86 ELANE (0.60) NPC1RAB9AALDH1A1KDM4EXBP1
SCHEMBL5378586 0.86 ALDH1A1 (0.66) NPC1RAB9AALDH1A1KDM4EXBP1
SCHEMBL5376982 0.85 RAB9A (0.46) NPC1RAB9AALDH1A1KDM4EXBP1
SCHEMBL5376168 0.84 C1R (0.66) F7F3C1RMEN1KMT2A
SCHEMBL5381518 0.82 MAPT (0.54) NPC1RAB9AALDH1A1KDM4EXBP1
SCHEMBL5376751 0.82 KDM4E (0.51) NPC1RAB9AALDH1A1KDM4EELANE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7244776-B2 Ultraviolet light absorbers CIBA SPECIALTY CHEMICALS CORPORATION (US) 2007-07-17 US disclosed
US-20070100031-A1 Ultraviolet light absorbers RAVICHANDRAN RAMANATHAN 2007-05-03 US disclosed
US-7173128-B2 Ultraviolet light absorbers CIBA SPECIALTY CHEMICALS CORPORATION (US) 2007-02-06 US disclosed
US-20040192684-A1 Ultraviolet light absorbers CIBA SPECIALTY CHEMICALS CORPORATION 2004-09-30 US disclosed
EP-1430038-A1 ULTRAVIOLET LIGHT ABSORBERS Ciba SC Holding AG (CH) 2004-06-23 EP disclosed
WO-2003016292-A1 ULTRAVIOLET LIGHT ABSORBERS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2003-02-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040192684-A1 Ultraviolet light absorbers UNG, MSH6, MAL2 NPC1 4195/4885RAB9A 3701/4885ALDH1A1 131/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.