SCHEMBL5376370

SCHEMBL5376370

COc1ccc2nc(-c3ccc(-c4ccccc4)cc3)oc(=O)c2c1

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 6/20 0.73
ALDH1A1 P00352 5/20 0.73
MAPT P10636 5/20 0.73
SMN1; SMN2 Q16637 5/20 0.73
RAB9A P51151 5/20 0.73
KDM4E B2RXH2 4/20 0.73
LMNA P02545 1/20 0.73
HPGD P15428 3/20 0.68
KMT2A Q03164 2/20 0.68
F2 P00734 1/20 0.68
C1R P00736 2/20 0.67
HSD17B10 Q99714 1/20 0.66
ELANE P08246 1/20 0.57
TP53 P04637 5/20 0.57
CTSG P08311 1/20 0.53
KLK7 P49862 1/20 0.53
CTRC Q99895 1/20 0.53
KLK14 Q9P0G3 1/20 0.53
KLK5 Q9Y337 1/20 0.53
RXFP1 Q9HBX9 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2537004 0.94 MAPT (0.72) NPC1ALDH1A1MAPTSMN1; SMN2RAB9A
SCHEMBL6563993 0.89 MAPT (0.65) NPC1ALDH1A1MAPTSMN1; SMN2RAB9A
SCHEMBL5381075 0.88 TP53 (0.65) NPC1ALDH1A1MAPTSMN1; SMN2RAB9A
SCHEMBL5384654 0.88 ALDH1A1 (0.64) NPC1ALDH1A1MAPTSMN1; SMN2RAB9A
SCHEMBL1463884 0.88 ALDH1A1 (0.75) NPC1ALDH1A1MAPTSMN1; SMN2RAB9A
SCHEMBL692832 0.86 ELANE (0.64) NPC1ALDH1A1MAPTSMN1; SMN2RAB9A
SCHEMBL5371556 0.85 ALDH1A1 (0.60) NPC1ALDH1A1MAPTSMN1; SMN2RAB9A
SCHEMBL11104577 0.85 POLB (0.61) NPC1ALDH1A1MAPTSMN1; SMN2RAB9A
SCHEMBL692625 0.85 ALDH1A1 (1.00) NPC1ALDH1A1MAPTSMN1; SMN2RAB9A
SCHEMBL29633759 0.85 ALDH1A1 (1.00) NPC1ALDH1A1MAPTSMN1; SMN2RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7244776-B2 Ultraviolet light absorbers CIBA SPECIALTY CHEMICALS CORPORATION (US) 2007-07-17 US disclosed
US-20070100031-A1 Ultraviolet light absorbers RAVICHANDRAN RAMANATHAN 2007-05-03 US disclosed
US-7173128-B2 Ultraviolet light absorbers CIBA SPECIALTY CHEMICALS CORPORATION (US) 2007-02-06 US disclosed
US-20040192684-A1 Ultraviolet light absorbers CIBA SPECIALTY CHEMICALS CORPORATION 2004-09-30 US disclosed
EP-1430038-A1 ULTRAVIOLET LIGHT ABSORBERS Ciba SC Holding AG (CH) 2004-06-23 EP disclosed
WO-2003016292-A1 ULTRAVIOLET LIGHT ABSORBERS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2003-02-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040192684-A1 Ultraviolet light absorbers UNG, MSH6, MAL2 NPC1 4195/4885ALDH1A1 131/4885MAPT 904/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.