Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Silver. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP3 | P05413 | 1/20 | 0.34 |
| ▸ | FABP4 | P15090 | 1/20 | 0.34 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NPY1R | P25929 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5388305 | 0.84 | FABP3 (0.49) | FABP3FABP4FABP5MEN1TP53 | |
| SCHEMBL178363 | 0.84 | FABP3 (0.49) | FABP3FABP4FABP5MEN1TP53 | |
| SCHEMBL5376952 | 0.83 | FABP3 (0.47) | FABP3FABP4FABP5MEN1TP53 | |
| SCHEMBL2955944 | 0.82 | NR1I2 (0.32) | MEN1TP53CYP3A4MAPTTSHR | |
| SCHEMBL9004701 | 0.81 | PDK1 (0.37) | MEN1TP53CYP3A4MAPTTSHR | |
| SCHEMBL5378739 | 0.81 | HPRT1 (0.36) | MEN1TP53CYP3A4MAPTTSHR | |
| SCHEMBL107210 | 0.75 | ALDH1A1 (0.35) | MEN1TSHRKMT2ATDP1ALDH1A1 | |
| SCHEMBL10293225 | 0.73 | PDK1 (0.33) | TSHRTDP1ALDH1A1HPGDNPSR1 | |
| SCHEMBL27583174 | 0.72 | FABP3 (0.38) | FABP3FABP4FABP5MEN1TP53 | |
| SCHEMBL9280441 | 0.71 | PDK1 (0.33) | MEN1TP53CYP3A4MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7220532-B2 | Chemical amplification type resist composition | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2007-05-22 | — | — | US | disclosed |
| US-7135268-B2 | Using aromatic sulfonate compound | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2006-11-14 | — | — | US | disclosed |
| US-20050031984-A1 | Chemical amplification type positive resist composition | SUMITOMO CHEMICAL COMPANY, LIMITED | 2005-02-10 | — | — | US | disclosed |
| US-20040053171-A1 | Chemical amplification type resist composition | SUMITOMO CHEMICAL COMPANY, LIMITED | 2004-03-18 | — | — | US | disclosed |
| US-20040029037-A1 | Amplification type positive resist composition | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2004-02-12 | — | — | US | disclosed |