Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Demannose. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | TOP1 | P11387 | 1/20 | 0.34 |
| ▸ | MPI | P34949 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Demannose SCHEMBL329074 | 1.00 | LMNA (0.50) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Demannose SCHEMBL7958057 | 1.00 | LMNA (0.50) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Demannose SCHEMBL3872401 | 1.00 | LMNA (0.50) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Galactose SCHEMBL6900501 | 1.00 | LMNA (0.50) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Demannose SCHEMBL27994608 | 0.98 | LMNA (0.48) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Demannose SCHEMBL9938071 | 0.98 | LMNA (0.48) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Demannose SCHEMBL2341216 | 0.98 | LMNA (0.48) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Demannose SCHEMBL28146511 | 0.95 | LMNA (0.50) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Demannose SCHEMBL1681820 | 0.94 | LMNA (0.44) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Demannose SCHEMBL11509811 | 0.94 | PDE4A (0.47) | LMNAL3MBTL1TDP1KDM4EPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 457 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023143530-A1 | JOINT REPAIR PROTEIN COMPOSITION, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 北京达尔文细胞生物科技有限公司 | 2023-08-03 | — | — | WO | claimed |
| WO-2022253090-A1 | EYE DROP COMPOSITION FOR PREVENTION OR TREATMENT OF OPHTHALMIC DISEASES AND PREPARATION METHOD THEREFOR | 苏州欧康维视生物科技有限公司 | 2022-12-08 | — | — | WO | claimed |
| WO-2022021786-A1 | TSL-1502 COMPOUND PHARMACEUTICAL COMPOSITION | 江苏天士力帝益药业有限公司 | 2022-02-03 | — | — | WO | claimed |
| WO-2021213327-A1 | COMPOSITION CONTAINING 7-ETHYL-10-HYDROXYCAMPTOTHECIN, PREPARATION METHOD THEREFOR AND USE THEREOF | 昆山新蕴达生物科技有限公司 (CN) | 2021-10-28 | — | — | WO | claimed |
| WO-2020034989-A1 | INJECTABLE PHARMACEUTICAL COMPOSITION AND PREPARATION METHOD THEREFOR | 江苏恒瑞医药股份有限公司 | 2020-02-20 | — | — | WO | claimed |
| CN-110312432-A | The confectionery and preparation method thereof of dual texture | 洲际大品牌有限责任公司 | 2019-10-08 | — | — | CN | claimed |
| CN-110199027-A | Cell-free protein synthesis system | 弗劳恩霍夫应用研究促进协会 | 2019-09-03 | — | — | CN | claimed |
| CN-109996548-A | PHARMACEUTICAL FORMULATIONS OF SUVOREXANT | 成药技术IP控股有限公司 | 2019-07-09 | — | — | CN | claimed |
| CN-105143847-B | Cell dyeing composition and application thereof | 三路影像公司 | 2019-05-28 | — | — | CN | claimed |
| CN-105816346-B | A kind of Tea Saponin face cleaning powder and preparation method thereof and application method | 浙江农林大学 | 2019-05-17 | — | — | CN | claimed |
| CN-105919133-A | Health food composition containing vatica mangachapoi and capable of smoothing intestine and relieving constipation and preparation method thereof | 惠州同富康生物科技有限公司 | 2016-09-07 | — | — | CN | claimed |
| CN-105744929-A | Continuous release compositions made from hyaluronic acid, and therapeutic applications of same | 真生物技术公司 | 2016-07-06 | — | — | CN | claimed |
| CN-105053493-A | Tooth care chewing gum | JIESHOU ZHAOLONG FOOD CO LTD | 2015-11-18 | — | — | CN | claimed |
| CN-104920773-A | Toothpaste chewing gum | JIESHOU ZHAOLONG FOOD CO LTD | 2015-09-23 | — | — | CN | claimed |
| CN-104920770-A | Healthcare chewing gum | JIESHOU ZHAOLONG FOOD CO LTD | 2015-09-23 | — | — | CN | claimed |
| CN-101172104-A | Processes of making and using pharmaceutical formulations of antineoplastic agents | SCHERING CORP (US) | 2008-05-07 | — | — | CN | claimed |
| CN-100346784-C | pharmaceutical formulations of antineoplastic agents, in particular temozolomide, preparation method and use thereof | SCHERING CORP (US) | 2007-11-07 | — | — | CN | claimed |
| CN-1635871-A | pharmaceutical formulations of antineoplastic agents, in particular temozolomide, preparation method and use thereof | SCHERING CORP (US) | 2005-07-06 | — | — | CN | claimed |
| CN-1075737-C | Method and device for the provocation of air passage narrowing and/or the induction of sputum | CENT SYDNEY AREA HEALTH SERV (AU) | 2001-12-05 | — | — | CN | claimed |
| CN-1142190-A | Method and apparatus for inducing airway narrowing and/or inducing sputum production | CENTRAL SYNDNEY AREA HEALTH SE (AU) | 1997-02-05 | — | — | CN | claimed |