Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.48 |
| ▸ | IDO1 | P14902 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16123203 | 0.87 | ALDH1A1 (0.48) | RAB9AALDH1A1CA12CA1CA2 | |
| SCHEMBL19175184 | 0.84 | CA12 (0.47) | RAB9AALDH1A1CA12CA1CA2 | |
| SCHEMBL14660487 | 0.83 | TP53 (0.57) | RAB9AS1PR4ALDH1A1IDO1CA12 | |
| SCHEMBL6261344 | 0.82 | ALDH1A1 (0.51) | RAB9AALDH1A1CA12CA1CA2 | |
| SCHEMBL4573884 | 0.81 | CA12 (0.51) | ALDH1A1IDO1CA12CA1CA2 | |
| SCHEMBL3452611 | 0.81 | MAPT (0.54) | RAB9AALDH1A1CA12CA1CA2 | |
| SCHEMBL7434383 | 0.80 | ALDH1A1 (0.56) | RAB9AALDH1A1IDO1CA12CA1 | |
| SCHEMBL6260157 | 0.80 | MAPT (0.53) | RAB9AALDH1A1CA12CA1CA2 | |
| SCHEMBL360813 | 0.80 | RAB9A (0.60) | RAB9AALDH1A1IDO1CA12CA1 | |
| SCHEMBL3453194 | 0.80 | IDO1 (0.60) | RAB9AS1PR4ALDH1A1IDO1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202244-B2 | Chk-1 inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20050176733-A1 | Chk-1 inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-08-11 | — | — | US | disclosed |
| WO-2005072733-A1 | DYARYLUREA COMPOUNDS AS CHK-1 INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-08-11 | — | — | WO | disclosed |
| US-20040014765-A1 | Chk-1 inhibitors | MILLENNIUM PHARMACEUTICALS, INC. | 2004-01-22 | — | — | US | disclosed |
| WO-2003101444-A1 | DIARYLUREA COMPOUNDS AND DERIVATIVES AS CHK-1 INHIBITORS FOR THE TREATMENT OF CANCER | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2003-12-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040014765-A1 | Chk-1 inhibitors | CHKA, CHKB, CHEK1 | RAB9A 3026/4885S1PR4 1658/4885ALDH1A1 4635/4885 |
| US-20050176733-A1 | Chk-1 inhibitors | CHEK1, CHEK2, CHKA | RAB9A 2714/4885S1PR4 2110/4885ALDH1A1 3770/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.