Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MAP2K4 | P45985 | 8/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.40 |
| ▸ | MAPKAPK3 | Q16644 | 5/20 | 0.40 |
| ▸ | MAPK6 | Q16659 | 5/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.40 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.40 |
| ▸ | TTK | P33981 | 3/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.39 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | FER | P16591 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | MARK3 | P27448 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14514472 | 0.86 | MKNK1 (0.60) | MKNK1MAP2K4MAPK1MAPKAPK3MAPK6 | |
| SCHEMBL5073584 | 0.84 | CSNK1D (0.51) | MKNK1MAP2K4MAPK1MAPKAPK3MAPK6 | |
| SCHEMBL5381923 | 0.84 | FGFR1 (0.46) | MKNK1MAP2K4MAPK1MAPKAPK3MAPK6 | |
| SCHEMBL5374429 | 0.84 | MAP2K4 (0.55) | MKNK1MAP2K4MAPK1MAPKAPK3MAPK6 | |
| SCHEMBL5378044 | 0.84 | MKNK1 (0.44) | MKNK1MAP2K4MAPK1MAPKAPK3MAPK6 | |
| SCHEMBL5372930 | 0.83 | MKNK1 (0.49) | MKNK1MAP2K4MAPK1MAPKAPK3MAPK6 | |
| SCHEMBL8268311 | 0.82 | PRKAG1 (0.49) | MKNK1MAP2K4MAPK1MAPKAPK3MAPK6 | |
| SCHEMBL5381579 | 0.81 | NTRK1 (0.44) | MKNK1MAP2K4MAPK1MAPKAPK3MAPK6 | |
| SCHEMBL5381918 | 0.80 | MAP2K4 (0.64) | MKNK1MAP2K4MAPK1MAPKAPK3MAPK6 | |
| SCHEMBL5378750 | 0.80 | TTK (0.62) | MKNK1MAP2K4MAPK1MAPKAPK3MAPK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7211594-B2 | Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith | SIGNAL PHARMACEUTICALS, LLC (US) | 2007-05-01 | — | — | US | disclosed |
| US-20050261365-A1 | Transthyretin stabilization | THE SCRIPPS RESEARCH INSTITUTE (US) | 2005-11-24 | — | — | US | disclosed |
| US-20050009876-A1 | Indazole compounds, compositions thereof and methods of treatment therewith | SIGNAL PHARMACEUTICALS, LLC | 2005-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261365-A1 | Transthyretin stabilization | TTR, TTPA, ALB | MKNK1 3308/4885MAP2K4 4261/4885MAPK1 3603/4885 |
| US-20050009876-A1 | Indazole compounds, compositions thereof and methods of treatment therewith | GPR119, JAK3, IGF1R | MKNK1 65/4885MAP2K4 385/4885MAPK1 52/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.