Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 3/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1063053 | 0.88 | F2 (0.60) | F2KMT2AMEN1HTTSMN1; SMN2 | |
| SCHEMBL5377669 | 0.79 | HDAC6 (0.49) | F2SLC6A2SLC6A4HDAC6POLB | |
| SCHEMBL1064732 | 0.74 | F2 (0.56) | F2SLC6A2SLC6A4KMT2AMEN1 | |
| SCHEMBL5732386 | 0.73 | MAPK11 (0.48) | SLC6A2SLC6A4HDAC6POLBACHE | |
| SCHEMBL1062702 | 0.73 | F2 (0.64) | F2KMT2AMEN1HTTSMN1; SMN2 | |
| SCHEMBL7449374 | 0.72 | CCR3 (0.60) | SLC6A2SLC6A4KMT2AMEN1HTT | |
| SCHEMBL1064729 | 0.71 | F2 (0.52) | F2KMT2AMEN1HTTSMN1; SMN2 | |
| SCHEMBL5378029 | 0.71 | SLC6A2 (0.47) | F2SLC6A2SLC6A4HDAC6KMT2A | |
| SCHEMBL5369707 | 0.71 | HDAC6 (0.48) | F2SLC6A2SLC6A4HDAC6ACHE | |
| SCHEMBL5374680 | 0.71 | ACHE (0.56) | SLC6A2SLC6A4ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189739-B2 | Compounds and methods to treat cardiac failure and other disorders | SCIOS, INC. (US) | 2007-03-13 | — | — | US | disclosed |
| EP-1080078-B1 | HETEROCYCLIC COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS | SCIOS INC (US) | 2006-02-01 | — | — | EP | disclosed |
| US-6589954-B1 | Indoles, benzimidazoles and benztriazoles which are substituted at the 5 or 6 position with a substituent comprising an aromatic moiety linked through a piperazine ring to said indole, benzimidazole or benztriazole are useful | SCIOS, INC. | 2003-07-08 | — | — | US | disclosed |
| US-6340685-B1 | ANTIINFLAMMATORY AGENTS | SCIOS, INC. | 2002-01-22 | — | — | US | disclosed |