Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK11 | Q15759 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5377669 | 0.92 | HDAC6 (0.49) | HDAC6SLC6A2SLC6A4ACHEKCNH2 | |
| SCHEMBL5733936 | 0.77 | HDAC6 (0.52) | HDAC6KCNH2HRH3POLB | |
| SCHEMBL7449374 | 0.77 | CCR3 (0.60) | SLC6A2SLC6A4 | |
| SCHEMBL1063730 | 0.77 | MGLL (0.58) | MAPK14KCNH2HRH3 | |
| SCHEMBL7076381 | 0.75 | SIGMAR1 (0.48) | HDAC6SLC6A2SLC6A4ACHEKCNH2 | |
| SCHEMBL5377733 | 0.73 | F2 (0.54) | HDAC6SLC6A2SLC6A4ACHEPOLB | |
| SCHEMBL5374680 | 0.73 | ACHE (0.56) | MAPK14SLC6A2SLC6A4ACHE | |
| SCHEMBL231079 | 0.72 | MAPK11 (0.55) | MAPK11MAPK14HDAC6POLB | |
| SCHEMBL31636989 | 0.71 | MAPK11 (0.56) | MAPK11MAPK14HDAC6POLB | |
| SCHEMBL5373096 | 0.70 | GRIN2B (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1080078-B1 | HETEROCYCLIC COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS | SCIOS INC (US) | 2006-02-01 | — | — | EP | disclosed |