Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 12/20 | 0.74 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.74 |
| ▸ | TP53 | P04637 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.53 |
| ▸ | GPR39 | O43194 | 1/20 | 0.51 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5785800 | 0.85 | PTGS2 (1.00) | PTGS2PTGS1TP53SMN1; SMN2MAPT | |
| SCHEMBL5379548 | 0.85 | PTGS2 (0.54) | PTGS2PTGS1TP53SMN1; SMN2MAPT | |
| SCHEMBL14488606 | 0.84 | TP53 (0.60) | PTGS2PTGS1TP53SMN1; SMN2MAPT | |
| SCHEMBL14499102 | 0.79 | TP53 (0.65) | PTGS2PTGS1TP53SMN1; SMN2MAPT | |
| SCHEMBL5787875 | 0.77 | PTGS2 (0.78) | PTGS2PTGS1TP53SMN1; SMN2MAPT | |
| SCHEMBL5375362 | 0.76 | SDHB (0.60) | PTGS2PTGS1TP53SMN1; SMN2MAPT | |
| SCHEMBL24335036 | 0.76 | PTGS2 (0.83) | PTGS2PTGS1TP53MAPTADORA2A | |
| SCHEMBL5787610 | 0.76 | PTGS2 (1.00) | PTGS2PTGS1TP53SMN1; SMN2MAPT | |
| SCHEMBL5788345 | 0.76 | PTGS2 (0.81) | PTGS2PTGS1TP53SMN1; SMN2MAPT | |
| SCHEMBL5373896 | 0.75 | PTGS2 (0.75) | PTGS2PTGS1MAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235560-B2 | Pyrimidine derivative as selective COX-2 inhibitors | GLAXO GROUP LIMITED (GB) | 2007-06-26 | — | — | US | claimed |
| EP-1546128-B1 | PYRIMIDINE DERIVATIVES AS SELECTIVE COX-2 INHIBITORS | GLAXO GROUP LTD (GB) | 2006-05-03 | — | — | EP | claimed |
| US-20060040967-A1 | Pyrimidine derivative as selelctive cox-2 inhibitors | GLAXO GROUP LIMITED (GB) | 2006-02-23 | — | — | US | claimed |
| EP-1546128-A1 | PYRIMIDINE DERIVATIVES AS SELECTIVE COX-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2005-06-29 | — | — | EP | claimed |
| WO-2004018452-A1 | PYRIMIDINE DERIVATIVES AS SELECTIVE COX-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-03-04 | — | — | WO | claimed |
| US-7235560-B2 | Pyrimidine derivative as selective COX-2 inhibitors | GLAXO GROUP LIMITED (GB) | 2007-06-26 | — | — | US | disclosed |
| EP-1546128-B1 | PYRIMIDINE DERIVATIVES AS SELECTIVE COX-2 INHIBITORS | GLAXO GROUP LTD (GB) | 2006-05-03 | — | — | EP | disclosed |
| US-20060040967-A1 | Pyrimidine derivative as selelctive cox-2 inhibitors | GLAXO GROUP LIMITED (GB) | 2006-02-23 | — | — | US | disclosed |
| EP-1546128-A1 | PYRIMIDINE DERIVATIVES AS SELECTIVE COX-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004018452-A1 | PYRIMIDINE DERIVATIVES AS SELECTIVE COX-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-03-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060040967-A1 | Pyrimidine derivative as selelctive cox-2 inhibitors | PTGES2, PTGS2, DPYD | PTGS2 2/4885PTGS1 5/4885TP53 3849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.