Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.54 |
| ▸ | GPR39 | O43194 | 1/20 | 0.51 |
| ▸ | VCP | P55072 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5378591 | 0.85 | PTGS2 (0.74) | PTGS2PTGS1GPR39SMN1; SMN2MAPT | |
| SCHEMBL22827974 | 0.71 | PTGS2 (0.71) | PTGS2PTGS1VCP | |
| SCHEMBL22828104 | 0.71 | PTGS2 (0.75) | PTGS2PTGS1SMN1; SMN2MAPTLMNA | |
| SCHEMBL24334967 | 0.71 | PTGS2 (0.64) | PTGS2PTGS1GPR39 | |
| SCHEMBL14488606 | 0.71 | TP53 (0.60) | PTGS2PTGS1SMN1; SMN2HTTMAPT | |
| SCHEMBL5889066 | 0.70 | PTGS2 (0.72) | PTGS2PTGS1VCPSMN1; SMN2MAPT | |
| SCHEMBL5785800 | 0.70 | PTGS2 (1.00) | PTGS2PTGS1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL6643434 | 0.69 | ADRA2B (0.70) | SMN1; SMN2LMNAKMT2AMEN1POLB | |
| SCHEMBL13329877 | 0.68 | LMNA (0.77) | SMN1; SMN2HTTMAPTLMNAKDM4E | |
| SCHEMBL13589551 | 0.68 | RORC (0.53) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235560-B2 | Pyrimidine derivative as selective COX-2 inhibitors | GLAXO GROUP LIMITED (GB) | 2007-06-26 | — | — | US | disclosed |
| EP-1546128-B1 | PYRIMIDINE DERIVATIVES AS SELECTIVE COX-2 INHIBITORS | GLAXO GROUP LTD (GB) | 2006-05-03 | — | — | EP | disclosed |
| US-20060040967-A1 | Pyrimidine derivative as selelctive cox-2 inhibitors | GLAXO GROUP LIMITED (GB) | 2006-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060040967-A1 | Pyrimidine derivative as selelctive cox-2 inhibitors | PTGES2, PTGS2, DPYD | PTGS2 2/4885PTGS1 5/4885GPR39 1803/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.