Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 7/20 | 0.38 |
| ▸ | AURKA | O14965 | 6/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.35 |
| ▸ | TTK | P33981 | 3/20 | 0.35 |
| ▸ | GSK3A | P49840 | 3/20 | 0.34 |
| ▸ | GSK3B | P49841 | 3/20 | 0.34 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.34 |
| ▸ | CLK2 | P49760 | 2/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.34 |
| ▸ | CLK3 | P49761 | 1/20 | 0.34 |
| ▸ | CPT2 | P23786 | 1/20 | 0.33 |
| ▸ | CPT1A | P50416 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.33 |
| ▸ | PRKCG | P05129 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | AKT1 | P31749 | 2/20 | 0.33 |
| ▸ | AKT2 | P31751 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5397809 | 0.91 | PTPN1 (0.36) | FGFR1DDR2CPT2CPT1AMAP4K4 | |
| SCHEMBL5378724 | 0.88 | SMN1; SMN2 (0.39) | FGFR1DDR2MAP4K4MAPK1 | |
| SCHEMBL5391965 | 0.86 | FGFR1 (0.36) | FGFR1DDR2CPT2CPT1AMAP4K4 | |
| SCHEMBL5380109 | 0.84 | L3MBTL1 (0.39) | AURKBAURKAFGFR1DDR2MAP4K4 | |
| SCHEMBL5380244 | 0.84 | MMP2 (0.36) | FGFR1DDR2TTKMAP4K4MAPK1 | |
| SCHEMBL14554188 | 0.84 | MAP4K4 (0.36) | FGFR1DDR2CPT2CPT1AMAP4K4 | |
| SCHEMBL5373247 | 0.84 | ECE1 (0.38) | FGFR1DDR2CPT2CPT1AMAP4K4 | |
| SCHEMBL5372575 | 0.83 | MAP4K4 (0.38) | FGFR1DDR2CPT2CPT1AMAP4K4 | |
| SCHEMBL5386995 | 0.83 | MAPT (0.38) | AURKBAURKAFGFR1DDR2MAPK8 | |
| SCHEMBL5383426 | 0.83 | MAP4K4 (0.38) | FGFR1DDR2MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7211594-B2 | Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith | SIGNAL PHARMACEUTICALS, LLC (US) | 2007-05-01 | — | — | US | disclosed |
| US-20040127536-A1 | Methods for treating an inflammatory condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC | 2004-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127536-A1 | Methods for treating an inflammatory condition or inhibiting JNK | MAPK1, MAP3K1, MAPKAPK2 | AURKB 2180/4885AURKA 3307/4885FGFR1 701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.