Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.55 |
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.55 |
| ▸ | PDE10A | Q9Y233 | 9/20 | 0.51 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5373709 | 0.90 | FFAR1 (0.61) | CYSLTR2CYSLTR1PDE10AALOX5APFFAR1 | |
| SCHEMBL5397393 | 0.88 | HDAC1 (0.41) | CYSLTR2CYSLTR1ALOX5APFFAR1ALOX5 | |
| SCHEMBL5397526 | 0.83 | CYSLTR2 (0.47) | CYSLTR2CYSLTR1ALOX5APFFAR1AKR1B1 | |
| SCHEMBL5393783 | 0.83 | FFAR1 (0.66) | CYSLTR2CYSLTR1PDE10AFFAR1AKR1B1 | |
| SCHEMBL5374912 | 0.83 | HDAC1 (0.44) | CYSLTR2CYSLTR1ALOX5APFFAR1ALOX5 | |
| SCHEMBL5382038 | 0.83 | KMT2A (0.47) | — | |
| SCHEMBL5376872 | 0.82 | FFAR1 (0.53) | FFAR1 | |
| SCHEMBL5373797 | 0.80 | ALDH1A1 (0.47) | CYSLTR2CYSLTR1 | |
| SCHEMBL5374476 | 0.79 | RAB9A (0.47) | CYSLTR2CYSLTR1PDE10AALOX5 | |
| SCHEMBL5385345 | 0.78 | PPARG (0.43) | FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7179823-B1 | 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-20 | — | — | US | disclosed |
| EP-1457490-A1 | 5-membered N-heterocyclic compounds with hypoglycemic and hypolipidemic activity | Takeda Chemical Industries, Ltd. (JP) | 2004-09-15 | — | — | EP | disclosed |
| EP-1228067-B1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-07-14 | — | — | EP | disclosed |
| EP-1228067-A1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGYLCEMIC AND HYPOLIPIDEMIC ACTIVITY | Takeda Chemical Industries, Ltd. (JP) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001038325-A1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-31 | — | — | WO | disclosed |