SCHEMBL5380250

SCHEMBL5380250

FC(F)(F)c1ccccc1Cc1ccccc1

nearest known ligand 0.56

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.56
ALDH1A1 P00352 2/20 0.56
ATM Q13315 2/20 0.56
LTA4H P09960 1/20 0.53
IDO1 P14902 2/20 0.52
CALM1 P0DP23 1/20 0.46
HTR2A P28223 1/20 0.45
AR P10275 1/20 0.45
POLB P06746 2/20 0.44
GAA P10253 2/20 0.44
MAOB P27338 1/20 0.44
POLQ O75417 1/20 0.44
BCL2 P10415 1/20 0.43
BCL2L1 Q07817 1/20 0.43
HDAC1 Q13547 1/20 0.43
HDAC8 Q9BY41 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
TDP1 Q9NUW8 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12869583 0.85 CALM1 (0.44) KDM4EALDH1A1ATMLTA4HIDO1
SCHEMBL14871016 0.84 KDM4E (0.52) KDM4EALDH1A1ATMLTA4HIDO1
SCHEMBL29024749 0.84 KDM4E (0.46) KDM4EALDH1A1ATMLTA4HIDO1
SCHEMBL9861938 0.83 BCL2 (0.46) KDM4EALDH1A1ATMLTA4HIDO1
SCHEMBL9861521 0.83 LTA4H (0.47) KDM4EALDH1A1ATMLTA4HIDO1
SCHEMBL10786732 0.81 HDAC1 (0.50) KDM4EALDH1A1ATMLTA4HIDO1
SCHEMBL17671285 0.81 KDM4E (0.54) KDM4EALDH1A1ATMIDO1POLB
SCHEMBL5764360 0.80 CALM1 (0.48) KDM4EALDH1A1ATMCALM1HTR2A
SCHEMBL5270747 0.80 LTA4H (0.48) KDM4EALDH1A1ATMLTA4HIDO1
SCHEMBL5255556 0.79 POLQ (0.50) ALDH1A1POLQBCL2BCL2L1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110497709-A A kind of novel thermosensitive recording materials and preparation method thereof JIANGSU AOLUNDA HIGH TECH IND CO LTD 2019-11-26 CN claimed
WO-2023149761-A1 ORGANIC MOLECULES USABLE IN OPTOELECTRONIC DEVICES SAMSUNG DISPLAY CO., LTD. (KR) 2023-08-10 WO disclosed
CN-110497709-A A kind of novel thermosensitive recording materials and preparation method thereof JIANGSU AOLUNDA HIGH TECH IND CO LTD 2019-11-26 CN disclosed
CN-107206822-B Recording materials and recording sheet 日本曹达株式会社 2019-11-26 CN disclosed
CN-110431696-A Secondary cell adhesive composition NEC CORP 2019-11-08 CN disclosed
CN-107614277-B Thermosensitive recording body with the middle layer comprising hollow particle 赛登化学株式会社 2019-11-05 CN disclosed
CN-110402511-A Secondary cell adhesive composition NEC CORP 2019-11-01 CN disclosed
CN-105026171-B Thermal recording medium 株式会社理光 2018-12-14 CN disclosed
CN-108701831-A Secondary cell adhesive 日本电气株式会社 2018-10-23 CN disclosed
CN-107614277-A Thermosensitive recording body with the intermediate layer comprising hollow particle 赛登化学株式会社 2018-01-19 CN disclosed
CN-101981154-A Base generator, photosensitive resin composition, material for pattern formation comprising the photosensitive resin composition, method for pattern formation using the photosensitive resin composition, and article DAINIPPON PRINTING CO LTD 2011-02-23 CN disclosed
CN-101874078-A Polyimide-based composite material and film thereof MITSUI CHEMICALS INC 2010-10-27 CN disclosed
CN-101868444-A Acetylenic compound, salt thereof, condensate thereof, and composition thereof FUJIFILM CORP 2010-10-20 CN disclosed
CN-101808982-A Acetylene compound FUJIFILM CORP 2010-08-18 CN disclosed
CN-101015032-A Envelope for image display, sealing material, sealing method, and image display ASAHI GLASS CO LTD (JP) 2007-08-08 CN disclosed
US-7253198-B2 Hydroxyethylamine derivatives for the treatment of Alzheimer's disease GLAXO GROUP LIMITED (GB) 2007-08-07 US disclosed
US-20060025459-A1 Hydroxyethylamine derivatives for the treatment of alzheimer's disease GLAXO GROUP LIMITED (GB) 2006-02-02 US disclosed
US-5919793-A QUINUCLIDINE DERIVATIVES, SQUALENE SYNTHETASE INHIBITORS, ANTICHOLESTEROL AGENTS ZENECA LIMITED (GB) 1999-07-06 US disclosed
EP-0696284-A1 HETEROCYCLIC DERIVATIVES ZENECA LIMITED (GB) 1996-02-14 EP disclosed
WO-1994025459-A1 HETEROCYCLIC DERIVATIVES ZENECA LIMITED (GB) 1994-11-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060025459-A1 Hydroxyethylamine derivatives for the treatment of alzheimer's disease BACE2, PSEN2, BACE1 KDM4E 1129/4885ALDH1A1 3102/4885ATM 870/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.