Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | MMP1 | P03956 | 2/20 | 0.47 |
| ▸ | MMP2 | P08253 | 2/20 | 0.47 |
| ▸ | MMP8 | P22894 | 2/20 | 0.47 |
| ▸ | CTSK | P43235 | 6/20 | 0.42 |
| ▸ | CTSL | P07711 | 5/20 | 0.42 |
| ▸ | CTSS | P25774 | 5/20 | 0.42 |
| ▸ | CTSB | P07858 | 3/20 | 0.39 |
| ▸ | MMP13 | P45452 | 2/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.38 |
| ▸ | MMP12 | P39900 | 2/20 | 0.37 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2246821 | 1.00 | NPC1 (0.51) | NPC1RAB9AMMP1MMP2MMP8 | |
| SCHEMBL8272256 | 1.00 | NPC1 (0.51) | NPC1RAB9AMMP1MMP2MMP8 | |
| SCHEMBL2549237 | 1.00 | NPC1 (0.51) | NPC1RAB9AMMP1MMP2MMP8 | |
| SCHEMBL2252330 | 0.90 | NPC1 (0.53) | NPC1RAB9ACTSKCTSLCTSS | |
| SCHEMBL5377990 | 0.87 | MMP2 (0.51) | MMP1MMP2MMP8MMP13MMP3 | |
| SCHEMBL2244739 | 0.87 | MMP2 (0.51) | MMP1MMP2MMP8MMP13MMP3 | |
| SCHEMBL2246882 | 0.86 | MMP1 (0.50) | MMP1MMP2MMP8MMP13MMP3 | |
| SCHEMBL2546161 | 0.86 | MMP1 (0.50) | MMP1MMP2MMP8MMP13MMP3 | |
| SCHEMBL2244432 | 0.78 | S1PR1 (0.41) | MMP1MMP2MMP8MMP13MMP3 | |
| SCHEMBL2552852 | 0.78 | S1PR1 (0.41) | MMP1MMP2MMP8MMP13MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1771421-A1 | N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF | Applied Research Systems ARS Holding N.V. (AN) | 2007-04-11 | — | — | EP | disclosed |
| WO-2006010751-A1 | N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2006-02-02 | — | — | WO | disclosed |