Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 3/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.43 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | XDH | P47989 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5384159 | 0.83 | GSK3B (0.64) | GSK3BXDHSMN1; SMN2 | |
| SCHEMBL5400045 | 0.80 | GSK3B (0.69) | KMT2ACYP19A1GSK3BALKALDH1A1 | |
| SCHEMBL5382536 | 0.78 | CYP19A1 (0.52) | KMT2ACYP19A1ALKALDH1A1CYP2A6 | |
| SCHEMBL5384455 | 0.76 | GSK3B (0.75) | KMT2ACYP19A1GSK3BALDH1A1HPGD | |
| SCHEMBL14935666 | 0.75 | GSK3B (0.73) | KMT2ACYP19A1GSK3BALDH1A1HPGD | |
| SCHEMBL5381426 | 0.75 | GSK3B (0.78) | KMT2ACYP19A1GSK3BALDH1A1HPGD | |
| SCHEMBL10840151 | 0.73 | XDH (0.52) | KMT2ACYP19A1GSK3BALDH1A1HPGD | |
| SCHEMBL5376063 | 0.73 | GSK3B (0.76) | KMT2ACYP19A1GSK3BALDH1A1HPGD | |
| SCHEMBL14935661 | 0.72 | GSK3B (0.55) | KMT2AGSK3BPOLBPTGES | |
| SCHEMBL2239607 | 0.71 | CYP2A6 (0.59) | KMT2ACYP19A1GSK3BALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7256199-B1 | Pyrimidone derivatives | MITSUBISHI CHEMICAL CORPORATION (JP) | 2007-08-14 | — | — | US | disclosed |
| EP-1115721-B1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEM CORP (JP) | 2003-12-10 | — | — | EP | disclosed |
| EP-1115721-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000018758-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2000-04-06 | — | — | WO | disclosed |