Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | GSTP1 | P09211 | 2/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5385365 | 0.90 | S1PR5 (0.51) | MEN1KMT2AGSTP1MAOBSMN1; SMN2 | |
| SCHEMBL7491027 | 0.89 | MEN1 (0.51) | MEN1KMT2AGSTP1SMN1; SMN2P2RY14 | |
| SCHEMBL5382479 | 0.87 | P2RY14 (0.47) | MEN1KMT2AHPGDCNR1GSTP1 | |
| SCHEMBL7539595 | 0.80 | MAOB (0.47) | MEN1KMT2AGSTP1MAOB | |
| SCHEMBL5382756 | 0.79 | MEN1 (0.43) | MEN1KMT2ALMNAGSTP1MAOB | |
| SCHEMBL5393626 | 0.78 | GSTP1 (0.45) | MEN1KMT2AGSTP1MAOBNPC1 | |
| SCHEMBL5377296 | 0.78 | PTGER3 (0.51) | MEN1KMT2ALMNAGSTP1P2RY14 | |
| SCHEMBL5377289 | 0.78 | PTGER3 (0.51) | MEN1KMT2ALMNAGSTP1P2RY14 | |
| SCHEMBL5377062 | 0.77 | LTB4R (0.46) | MEN1KMT2AGSTP1P2RY14PPARG | |
| SCHEMBL4460274 | 0.76 | MAOB (0.57) | MEN1KMT2ALMNAHPGDGSTP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7179823-B1 | 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-20 | — | — | US | disclosed |
| EP-1457490-A1 | 5-membered N-heterocyclic compounds with hypoglycemic and hypolipidemic activity | Takeda Chemical Industries, Ltd. (JP) | 2004-09-15 | — | — | EP | disclosed |
| EP-1228067-B1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-07-14 | — | — | EP | disclosed |