Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.71 |
| ▸ | MEN1 | O00255 | 3/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | MAOA | P21397 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | CA7 | P43166 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.55 |
| ▸ | DRD1 | P21728 | 1/20 | 0.55 |
| ▸ | DRD5 | P21918 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | CRHBP | P24387 | 1/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.48 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.48 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11713631 | 0.87 | KMT2A (0.66) | KMT2AMEN1ALDH1A1LMNAMAOA | |
| SCHEMBL11713664 | 0.84 | KMT2A (0.73) | KMT2AMEN1ALDH1A1LMNAMAOA | |
| SCHEMBL11710065 | 0.83 | KMT2A (0.71) | KMT2AMEN1ALDH1A1LMNAMAOA | |
| SCHEMBL14646680 | 0.81 | KMT2A (1.00) | KMT2AMEN1ALDH1A1LMNAMAOA | |
| SCHEMBL7849270 | 0.81 | KMT2A (1.00) | KMT2AMEN1ALDH1A1LMNAMAOA | |
| SCHEMBL13804033 | 0.81 | KMT2A (1.00) | KMT2AMEN1ALDH1A1LMNAMAOA | |
| SCHEMBL30789059 | 0.81 | KMT2A (0.68) | KMT2AMEN1ALDH1A1LMNAMAOA | |
| SCHEMBL11714295 | 0.80 | KMT2A (0.67) | KMT2AMEN1ALDH1A1LMNAMAOA | |
| Hydrochloric Acid SCHEMBL4772373 | 0.80 | KMT2A (0.97) | KMT2AMEN1ALDH1A1LMNAMAOA | |
| SCHEMBL16979273 | 0.80 | KMT2A (0.67) | KMT2AMEN1ALDH1A1LMNAMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8343961-B2 | Substituted heterocyclic compounds | ARQULE, INC. (US) | 2013-01-01 | — | — | US | disclosed |
| US-8343961-B2 | Substituted heterocyclic compounds | ARQULE, INC. (US) | 2013-01-01 | — | — | US | disclosed |
| US-8343961-B2 | Substituted heterocyclic compounds | ARQULE, INC. (US) | 2013-01-01 | — | — | US | disclosed |
| EP-2414361-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS | ArQule, Inc. (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114894-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS | ARQULE, INC. (US) | 2010-10-07 | — | — | WO | disclosed |
| WO-2010114894-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS | ARQULE, INC. (US) | 2010-10-07 | — | — | WO | disclosed |
| US-20100249115-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS | ARQULE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
| US-20100249115-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS | ARQULE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
| US-20100249115-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS | ARQULE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
| US-4001244-A | 1-ARYL-3,4-DIHYDRO-2(1H)-ISOQUINOLINE CARBONYL CHLORIDES | G. D. SEARLE & CO. (US) | 1977-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249115-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS | CYP11B2, GABBR1, CNR1 | KMT2A 628/4885MEN1 402/4885ALDH1A1 931/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.