Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MYC | P01106 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | ALPI | P09923 | 1/20 | 0.41 |
| ▸ | ALPG | P10696 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 7/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 3/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 3/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 3/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28313589 | 0.81 | TDP1 (0.55) | TDP1MAPK1ALDH1A1TSHRHSD17B10 | |
| SCHEMBL187588 | 0.81 | TDP1 (0.55) | TDP1MAPK1ALDH1A1TSHRHSD17B10 | |
| SCHEMBL30342247 | 0.81 | TDP1 (0.55) | TDP1MAPK1ALDH1A1TSHRHSD17B10 | |
| SCHEMBL29747008 | 0.79 | MAPK1 (0.53) | TDP1MAPK1ALDH1A1TSHRHSD17B10 | |
| Hydrogen Sulfide SCHEMBL28338492 | 0.79 | TDP1 (0.53) | TDP1MAPK1ALDH1A1TSHRHSD17B10 | |
| SCHEMBL3412053 | 0.77 | MYC (0.54) | TDP1MAPK1ALDH1A1TSHRHSD17B10 | |
| SCHEMBL133466 | 0.76 | TDP1 (0.43) | TDP1MAPK1ALDH1A1TSHRHSD17B10 | |
| Isothiocyanate SCHEMBL8352965 | 0.75 | TDP1 (0.46) | TDP1MAPK1ALDH1A1TSHRHSD17B10 | |
| SCHEMBL4252088 | 0.75 | KMT2A (0.45) | TDP1MAPK1ALDH1A1TSHRHSD17B10 | |
| SCHEMBL8619132 | 0.75 | MEN1 (0.46) | TDP1MAPK1ALDH1A1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10829803-B2 | Detection of nucleic acid targets using chemically reactive oligonucleotide probes | DXTERITY DIAGNOSTICS INCORPORATED (US) | 2020-11-10 | — | — | US | disclosed |
| US-20190106739-A1 | CHEMICAL LIGATION DEPENDENT PROBE AMPLIFICATION (CLPA) | DXTERITY DIAGNOSTICS INCORPORATED | 2019-04-11 | — | — | US | disclosed |
| US-10066257-B2 | Methods and compositions for detecting target nucleic acids | DXTERITY DIAGNOSTICS INCORPORATED (US) | 2018-09-04 | — | — | US | disclosed |
| US-9976177-B2 | Chemical ligation dependent probe amplification (CLPA) | DXTERITY DIAGNOSTICS INCORPORATED (US) | 2018-05-22 | — | — | US | disclosed |
| US-20180030520-A1 | METHODS AND COMPOSITIONS FOR DETECTING TARGET NUCLEIC ACIDS | DXTERITY DIAGNOSTICS INCORPORATED | 2018-02-01 | — | — | US | disclosed |
| US-9745616-B2 | Methods and compositions for detecting target nucleic acids | DXTERITY DIAGNOSTICS INCORPORATED (US) | 2017-08-29 | — | — | US | disclosed |
| EP-2765205-B1 | Chemical ligation dependent probe amplification (CLPA) | DXTERITY DIAGNOSTICS INC (US) | 2016-05-18 | — | — | EP | disclosed |
| EP-2710145-B1 | METHODS AND COMPOSITIONS FOR DETECTING TARGET NUCLEIC ACIDS | DXTERITY DIAGNOSTICS INC (US) | 2015-12-09 | — | — | EP | disclosed |
| EP-2765205-A1 | Chemical ligation dependent probe amplification (CLPA) | DXTerity Diagnostics Incorporated (US) | 2014-08-13 | — | — | EP | disclosed |
| US-20140171338-A1 | METHODS AND COMPOSITIONS FOR DETECTING TARGET NUCLEIC ACIDS | DXTERITY DIAGNOSTICS INCORPORATED (US) | 2014-06-19 | — | — | US | disclosed |
| EP-2710145-A1 | METHODS AND COMPOSITIONS FOR DETECTING TARGET NUCLEIC ACIDS | Dxterity Diagnostics Incorporated (US) | 2014-03-26 | — | — | EP | disclosed |
| EP-2677039-A2 | Detection of nucleic acid targets using chemically reactive oligonucleotide probes | Dxterity Diagnostics (US) | 2013-12-25 | — | — | EP | disclosed |
| US-20130005594-A1 | METHODS AND COMPOSITIONS FOR DETECTING TARGET NUCLEIC ACIDS | DXTERITY DIAGNOSTICS INCORPORATED (US) | 2013-01-03 | — | — | US | disclosed |
| WO-2012158967-A1 | METHODS AND COMPOSITIONS FOR DETECTING TARGET NUCLEIC ACIDS | DXTERITY DIAGNOSTICS INCORPORATED (US) | 2012-11-22 | — | — | WO | disclosed |
| EP-2414544-A1 | CHEMICAL LIGATION DEPENDENT PROBE AMPLIFICATION (CLPA) | DXTerity Diagnostics Incorporated (US) | 2012-02-08 | — | — | EP | disclosed |
| US-20100267585-A1 | Chemical ligation dependent probe amplification (CLPA) | DXTERITY DIAGNOSTICS | 2010-10-21 | — | — | US | disclosed |
| WO-2010114599-A1 | CHEMICAL LIGATION DEPENDENT PROBE AMPLIFICATION (CLPA) | DX TERITY DIAGNOSTICS INC. (US) | 2010-10-07 | — | — | WO | disclosed |
| EP-2021514-A2 | DETECTION OF NUCLEIC ACID TARGETS USING CHEMICALLY REACTIVE OLIGONUCLEOTIDE PROBES | Dxterity Diagnostics (US) | 2009-02-11 | — | — | EP | disclosed |
| US-20080124810-A1 | Detection of nucleic acid targets using chemically reactive oligonucleotide probes | DXTERITY DIAGNOSTICS (US) | 2008-05-29 | — | — | US | disclosed |
| WO-2007133703-A2 | DETECTION OF NUCLEIC ACID TARGETS USING CHEMICALLY REACTIVE OLIGONUCLEOTIDE PROBES | DXTERITY DIAGNOSTICS (US) | 2007-11-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080124810-A1 | Detection of nucleic acid targets using chemically reactive oligonucleotide probes | POLRMT, LIG4, LIG3 | TDP1 238/4885MAPK1 4778/4885ALDH1A1 2058/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.