Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 8/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.37 |
| ▸ | NPC1 | O15118 | 7/20 | 0.37 |
| ▸ | MEN1 | O00255 | 7/20 | 0.37 |
| ▸ | RAB9A | P51151 | 6/20 | 0.37 |
| ▸ | NSD2 | O96028 | 2/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | MYC | P01106 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL538420 | 0.76 | TDP1 (0.44) | TDP1MAPK1ALDH1A1TSHRHSD17B10 | |
| SCHEMBL7146501 | 0.76 | MAPT (0.42) | TDP1MAPK1ALDH1A1TSHRHSD17B10 | |
| SCHEMBL3720716 | 0.75 | MYC (0.52) | TDP1MAPK1ALDH1A1TSHRHSD17B10 | |
| SCHEMBL97296 | 0.73 | ALDH1A1 (0.45) | TDP1MAPK1ALDH1A1TSHRMAPT | |
| SCHEMBL28604415 | 0.73 | POLB (0.46) | TDP1MAPK1ALDH1A1TSHRHSD17B10 | |
| SCHEMBL28584348 | 0.73 | CA2 (0.53) | TDP1MAPK1ALDH1A1TSHRHSD17B10 | |
| SCHEMBL187588 | 0.72 | TDP1 (0.55) | TDP1MAPK1ALDH1A1TSHRHSD17B10 | |
| SCHEMBL30342247 | 0.72 | TDP1 (0.55) | TDP1MAPK1ALDH1A1TSHRHSD17B10 | |
| SCHEMBL28313589 | 0.72 | TDP1 (0.55) | TDP1MAPK1ALDH1A1TSHRHSD17B10 | |
| SCHEMBL133465 | 0.71 | MAPT (0.37) | TDP1MAPK1ALDH1A1TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0137539-B1 | N-SUBSTITUTED TETRAHYDROTHIAZINES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS PESTICIDES | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1988-05-04 | — | — | EP | claimed |
| US-20190337988-A1 | NOVEL TRANSPORTER CONSTRUCTS AND TRANSPORTER CARGO CONJUGATE MOLECULES | XIGEN INFLAMMATION LTD. (CY) | 2019-11-07 | — | — | US | disclosed |
| US-10023615-B2 | Efficient transport into white blood cells | XIGEN INFLAMMATION LTD. (CY) | 2018-07-17 | — | — | US | disclosed |
| CN-102256998-B | Novel transporter constructs and transporter cargo binding molecules | 希根因弗兰曼斯有限公司 | 2018-06-15 | — | — | CN | disclosed |
| EP-2361260-B1 | NOVEL TRANSPORTER CONSTRUCTS AND TRANSPORTER CARGO CONJUGATE MOLECULES | XIGEN INFLAMMATION LTD (CY) | 2016-08-17 | — | — | EP | disclosed |
| CN-102256999-B | Efficient transport to leukocytes | XIGEN INFLAMMATION LTD. (CY) | 2016-03-02 | — | — | CN | disclosed |
| EP-2947093-A1 | EFFICIENT TRANSPORT INTO WHITE BLOOD CELLS | Xigen Inflammation Ltd. (CY) | 2015-11-25 | — | — | EP | disclosed |
| EP-2361259-B1 | EFFICIENT TRANSPORT INTO WHITE BLOOD CELLS | XIGEN INFLAMMATION LTD (CY) | 2015-04-22 | — | — | EP | disclosed |
| US-20120142584-A1 | NOVEL TRANSPORTER CONSTRUCTS AND TRANSPORTER CARGO CONJUGATE MOLECULES | XIGEN, S.A. (CH) | 2012-06-07 | — | — | US | disclosed |
| US-20120058137-A1 | EFFICIENT TRANSPORT INTO WHITE BLOOD CELLS | XIGEN, S.A. (CH) | 2012-03-08 | — | — | US | disclosed |
| CN-102256999-A | Efficient transport to leukocytes | XIGEN SA | 2011-11-23 | — | — | CN | disclosed |
| CN-102256998-A | Novel transporter constructs and transporter cargo binding molecules | XIGEN SA | 2011-11-23 | — | — | CN | disclosed |
| EP-2361260-A1 | NOVEL TRANSPORTER CONSTRUCTS AND TRANSPORTER CARGO CONJUGATE MOLECULES | Xigen S.A. (CH) | 2011-08-31 | — | — | EP | disclosed |
| EP-2361259-A1 | EFFICIENT TRANSPORT INTO WHITE BLOOD CELLS | Xigen S.A. (CH) | 2011-08-31 | — | — | EP | disclosed |
| WO-2010072405-A1 | EFFICIENT TRANSPORT INTO WHITE BLOOD CELLS | XIGEN S.A. (CH) | 2010-07-01 | — | — | WO | disclosed |
| WO-2010072406-A1 | NOVEL TRANSPORTER CONSTRUCTS AND TRANSPORTER CARGO CONJUGATE MOLECULES | XIGEN S.A. (CH) | 2010-07-01 | — | — | WO | disclosed |
| WO-2010072275-A1 | EFFICIENT DELIVERY OF MEDICAMENTS INTO WHITE BLOOD CELLS | XIGEN S.A. (CH) | 2010-07-01 | — | — | WO | disclosed |
| WO-2010072228-A1 | NOVEL TRANSPORTER CONSTRUCTS AND TRANSPORTER CARGO CONJUGATE MOLECULES | XIGEN S.A. (CH) | 2010-07-01 | — | — | WO | disclosed |
| EP-0137539-B1 | N-SUBSTITUTED TETRAHYDROTHIAZINES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS PESTICIDES | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1988-05-04 | — | — | EP | disclosed |
| EP-0137539-A1 | N-substituted tetrahydrothiazines, process for their preparation, and their use as pesticides | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1985-04-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058137-A1 | EFFICIENT TRANSPORT INTO WHITE BLOOD CELLS | SLC2A1, SLC2A3, SLC2A2 | TDP1 2710/4885MAPK1 4308/4885ALDH1A1 848/4885 |
| US-20190337988-A1 | NOVEL TRANSPORTER CONSTRUCTS AND TRANSPORTER CARGO CONJUGATE MOLECULES | SLC43A1, SLCO2B1, SLC29A1 | TDP1 737/4885MAPK1 4200/4885ALDH1A1 1050/4885 |
| US-20120142584-A1 | NOVEL TRANSPORTER CONSTRUCTS AND TRANSPORTER CARGO CONJUGATE MOLECULES | SLC43A1, SLCO2B1, SLC29A1 | TDP1 737/4885MAPK1 4200/4885ALDH1A1 1050/4885 |
| US-10023615-B2 | Efficient transport into white blood cells | SLC2A1, SLC2A3, SLC2A2 | TDP1 2710/4885MAPK1 4308/4885ALDH1A1 848/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.