SCHEMBL5384445

SCHEMBL5384445

O=C(OC[C@H]1O[C@H](O)[C@H](OC(=O)c2ccccc2)[C@@H]1OC(=O)c1ccccc1)c1ccccc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
USP2 O75604 2/20 0.56
POLB P06746 2/20 0.56
MEN1 O00255 1/20 0.56
KMT2A Q03164 1/20 0.56
PTPN1 P18031 3/20 0.51
LGALS9 O00182 1/20 0.49
LGALS1 P09382 1/20 0.49
LGALS3 P17931 1/20 0.49
LGALS7; LGALS7B P47929 1/20 0.49
CA1 P00915 2/20 0.48
CA2 P00918 2/20 0.48
CA9 Q16790 1/20 0.48
ALDH1A1 P00352 2/20 0.47
PTPN2 P17706 1/20 0.45
PTPN11 Q06124 1/20 0.45
TSHR P16473 1/20 0.45
GAPDH P04406 2/20 0.45
MAPK1 P28482 2/20 0.44
TMPRSS2 O15393 1/20 0.44
PDE5A O76074 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15481991 1.00 USP2 (0.56) USP2POLBMEN1KMT2APTPN1
SCHEMBL6219702 1.00 USP2 (0.56) USP2POLBMEN1KMT2APTPN1
SCHEMBL5954035 1.00 USP2 (0.56) USP2POLBMEN1KMT2APTPN1
SCHEMBL8153332 1.00 USP2 (0.56) USP2POLBMEN1KMT2APTPN1
SCHEMBL13146097 1.00 USP2 (0.56) USP2POLBMEN1KMT2APTPN1
SCHEMBL17471512 1.00 USP2 (0.56) USP2POLBMEN1KMT2APTPN1
SCHEMBL5384438 1.00 USP2 (0.56) USP2POLBMEN1KMT2APTPN1
SCHEMBL17612312 1.00 USP2 (0.56) USP2POLBMEN1KMT2APTPN1
SCHEMBL8153327 1.00 USP2 (0.56) USP2POLBMEN1KMT2APTPN1
SCHEMBL25029339 0.99 USP2 (0.55) USP2POLBMEN1KMT2APTPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3184112-B1 SYNTHETIC INTERMEDIATE OF 1-(2-DEOXY-2-FLUORO-4-THIO-ß-D-ARABINOFURANOSYL)CYTOSINE FUJIFILM CORP (JP) 2020-12-23 EP disclosed
CN-107011168-B Synthesis intermediates of cytosines and synthesis intermediates of thionucleosides 富士胶片株式会社 2020-06-09 CN disclosed
US-10570112-B2 Synthetic intermediate of 1-(2-deoxy-2-fluoro-4-thio-β-D-arabinofuranosyl)cytosine, synthetic intermediate of thionucleoside, and method for producing the same FUJIFILM CORPORATION (JP) 2020-02-25 US disclosed
US-20180327377-A1 SYNTHETIC INTERMEDIATE OF 1-(2-DEOXY-2-FLUORO-4-THIO-ß-D-ARABINOFURANOSYL)CYTOSINE, SYNTHETIC INTERMEDIATE OF THIONUCLEOSIDE, AND METHOD FOR PRODUCING THE SAME FUJIFILM CORPORATION (JP) 2018-11-15 US disclosed
US-10093645-B2 Synthetic intermediate of 1-(2-deoxy-2-fluoro-4-thio-β-D-arabinofuranosyl)cytosine, synthetic intermediate of thionucleoside, and method for producing the same FUJIFILM CORPORATION (JP) 2018-10-09 US disclosed
EP-3184112-A1 SYNTHETIC INTERMEDIATE OF 1-(2-DEOXY-2-FLUORO-4-THIO-SS-D-ARABINOFURANOSYL)CYTOSINE Fujifilm Corporation (JP) 2017-06-28 EP disclosed
US-20160362389-A1 SYNTHETIC INTERMEDIATE OF 1-(2-DEOXY-2-FLUORO-4-THIO-ß-D-ARABINOFURANOSYL)CYTOSINE, SYNTHETIC INTERMEDIATE OF THIONUCLEOSIDE, AND METHOD FOR PRODUCING THE SAME FUJIFILM CORPORATION (JP) 2016-12-15 US disclosed
US-9475835-B2 Synthetic intermediate of 1-(2-deoxy-2-fluoro-4-thio-β-D-arabinofuranosyl) cytosine, synthetic intermediate of thionucleoside, and method for producing the same FUJIFILM CORPORATION (JP) 2016-10-25 US disclosed
US-20160024132-A1 SYNTHETIC INTERMEDIATE OF 1-(2-DEOXY-2-FLUORO-4-THIO-ß-D-ARABINOFURANOSYL) CYTOSINE, SYNTHETIC INTERMEDIATE OF THIONUCLEOSIDE, AND METHOD FOR PRODUCING THE SAME FUJIFILM CORPORATION (JP) 2016-01-28 US disclosed
US-9221865-B2 Synthetic intermediate of 1-(2-deoxy-2-fluoro-4-thio-β-D-arabinofuranosyl)cytosine, synthetic intermediate of thionucleoside, and method for producing the same FUJIFILM CORPORATION (JP) 2015-12-29 US disclosed
US-20020132263-A1 Enzyme detection/assay method and substrates NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2002-09-19 US disclosed
US-6379911-B2 ANALYZING NUCLEOSIDE HYDROLASES; DETECTING PARASITES ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY 2002-04-30 US disclosed
US-20010019823-A1 ENZYME DETECTION/ASSAY METHOD AND SUBSTRATES NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2001-09-06 US disclosed
US-6248878-B1 INCLUDING BASES 2-FLUOROPYRIDINE-3-YL, PYRIDINE-2-ONE-3-YL, PYRIDIN-2-(4-NITROPHENYLETHYL)-ONE-3-YL, 2-BROMOPYRIDINE-5-YL , PYRIDIN-2-ONE-5-YL, 2-AMINOPYRIDINE-5-YL, PYRIDIN-2-(4-NITROPHENYLETHYL)-ONE-5-YL; ANTISENSE/ANTICANCER AGENTS RIBOZYME PHARMACEUTICALS, INC. 2001-06-19 US disclosed
US-6069132-A PYRIMIDOPHOSOHAZOLE RING SYSTEM OF GIVEN STRUCTURE, THE TRIVALENT PHOSPHORUS OF THE RING SUBSTITUTED WITH VARIOUS GROUPS; NEW CLASS OF PHOSPHORUS CONTAINING HETEROCYCLES WITH APPLICATION IN MEDICAL, AGRICULTURAL AND INDUSTRIAL USE ARONEX PHARMACEUTICALS, INC. 2000-05-30 US disclosed
EP-0948511-A2 CHEMICAL SYNTHESIS OF NUCLEOSIDES ANALOGS AND THEIR INCORPORATION INTO POLYNUCLEOTIDES RIBOZYME PHARMACEUTICALS, INC. (US) 1999-10-13 EP disclosed
WO-1999008688-A1 PHOSPHAZOLE-CONTAINING NUCLEOSIDE ANALOGS, RELATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR USE IN IN VITRO MEDICINAL TREATMENTS ARONEX PHARMACEUTICALS, INC. (US) 1999-02-25 WO disclosed
WO-1998028317-A2 SYNTHESIS OF NUCLEOSIDES AND POLYNUCLEOTIDES RIBOZYME PHARMACEUTICALS, INC. (US) 1998-07-02 WO disclosed
US-4855417-A Anomeric deacetylation YEDA RESEARCH AND DEVELOPMENT COMPANY LTD (IL) 1989-08-08 US disclosed
US-4614719-A REACTION OF 1,2,4-TRIAZOLE-CARBOXAMIDE AND RIBOSE DONOR IN PRESENCE OF BREVEBACTERIUM CATALYST YAMASA SHOYU KABUSHIKI KAISHA (JP) 1986-09-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010019823-A1 ENZYME DETECTION/ASSAY METHOD AND SUBSTRATES PNP, TREH, XDH USP2 2730/4885POLB 309/4885MEN1 3024/4885
US-20160024132-A1 SYNTHETIC INTERMEDIATE OF 1-(2-DEOXY-2-FLUORO-4-THIO-ß-D-ARABINOFURANOSYL) CYTOSINE, SYNTHETIC INTERMEDIATE OF THIONUCLEOSIDE, AND METHOD FOR PRODUCING THE SAME TYMS, TYMP, RRM2B USP2 4437/4885POLB 19/4885MEN1 2212/4885
US-10093645-B2 Synthetic intermediate of 1-(2-deoxy-2-fluoro-4-thio-β-D-arabinofuranosyl)cytosine, synthetic intermediate of thionucleoside, and method for producing the same TYMS, TYMP, RRM2B USP2 4441/4885POLB 19/4885MEN1 2277/4885
US-10570112-B2 Synthetic intermediate of 1-(2-deoxy-2-fluoro-4-thio-β-D-arabinofuranosyl)cytosine, synthetic intermediate of thionucleoside, and method for producing the same TYMS, TYMP, RRM2B USP2 4441/4885POLB 19/4885MEN1 2277/4885
US-20160362389-A1 SYNTHETIC INTERMEDIATE OF 1-(2-DEOXY-2-FLUORO-4-THIO-ß-D-ARABINOFURANOSYL)CYTOSINE, SYNTHETIC INTERMEDIATE OF THIONUCLEOSIDE, AND METHOD FOR PRODUCING THE SAME TYMS, TYMP, RRM2B USP2 4437/4885POLB 19/4885MEN1 2212/4885
US-20180327377-A1 SYNTHETIC INTERMEDIATE OF 1-(2-DEOXY-2-FLUORO-4-THIO-ß-D-ARABINOFURANOSYL)CYTOSINE, SYNTHETIC INTERMEDIATE OF THIONUCLEOSIDE, AND METHOD FOR PRODUCING THE SAME TYMS, TYMP, RRM2B USP2 4437/4885POLB 19/4885MEN1 2212/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.