Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | STAT1 | P42224 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.48 |
| ▸ | LDHA | P00338 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.47 |
| ▸ | HPGDS | O60760 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5381418 | 0.93 | CYP19A1 (0.54) | CYP19A1HPGDNPY5RKMT2AKDM4E | |
| SCHEMBL5376057 | 0.87 | KMT2A (0.54) | CYP19A1HPGDNPY5RKMT2AKDM4E | |
| SCHEMBL19665231 | 0.85 | HPGD (0.53) | HPGDNPY5RKMT2AKDM4EALDH1A1 | |
| SCHEMBL5381545 | 0.84 | CDC7 (0.59) | HPGDNPY5RKDM4EALDH1A1GAA | |
| SCHEMBL31074829 | 0.81 | SCN2A (0.47) | CYP19A1HPGDNPY5RKMT2AKDM4E | |
| SCHEMBL5400044 | 0.80 | CYP2A6 (0.59) | CYP19A1NPY5RKMT2AALDH1A1PKN2 | |
| SCHEMBL5385542 | 0.79 | RAF1 (0.46) | HPGDNPY5RKMT2AALDH1A1GAA | |
| SCHEMBL5377577 | 0.77 | CDC7 (0.49) | HPGDNPY5RKDM4EALDH1A1MAPT | |
| SCHEMBL5384455 | 0.77 | GSK3B (0.75) | CYP19A1HPGDNPY5RKMT2AKDM4E | |
| SCHEMBL10840148 | 0.77 | CYP19A1 (0.52) | CYP19A1HPGDKMT2AALDH1A1PKN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7256199-B1 | Pyrimidone derivatives | MITSUBISHI CHEMICAL CORPORATION (JP) | 2007-08-14 | — | — | US | disclosed |
| EP-1115721-B1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEM CORP (JP) | 2003-12-10 | — | — | EP | disclosed |
| EP-1115721-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000018758-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2000-04-06 | — | — | WO | disclosed |