Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.65 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.57 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.57 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | ERN1 | O75460 | 2/20 | 0.55 |
| ▸ | ESR1 | P03372 | 8/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 8/20 | 0.49 |
| ▸ | NQO1 | P15559 | 1/20 | 0.47 |
| ▸ | NQO2 | P16083 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.42 |
| ▸ | ACLY | P53396 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28813263 | 0.98 | APP (0.67) | APPHSD17B1HSD17B2CA1CA2 | |
| SCHEMBL11959810 | 0.94 | APP (0.62) | APPHSD17B1HSD17B2CA1CA2 | |
| SCHEMBL24332557 | 0.89 | APP (0.62) | APPHSD17B1HSD17B2CA1CA2 | |
| SCHEMBL9976850 | 0.88 | APP (0.50) | APPHSD17B1HSD17B2CA1CA2 | |
| SCHEMBL31589824 | 0.88 | APP (0.56) | APPHSD17B1HSD17B2CA1CA2 | |
| SCHEMBL10045302 | 0.88 | APP (0.56) | APPHSD17B1HSD17B2CA1CA2 | |
| SCHEMBL5429670 | 0.88 | APP (0.75) | APPHSD17B1HSD17B2CA1CA2 | |
| SCHEMBL13477886 | 0.88 | APP (0.56) | APPHSD17B1HSD17B2CA1CA2 | |
| SCHEMBL9976854 | 0.88 | APP (0.48) | APPHSD17B1HSD17B2CA1CA2 | |
| SCHEMBL32677328 | 0.87 | APP (0.81) | APPHSD17B1HSD17B2CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115073420-A | Preparation method of 2-phenylbenzothiophene derivative | 陕西维世诺新材料有限公司 | 2022-09-20 | — | — | CN | claimed |
| EP-0671454-B1 | Process for removal of heteroatoms | EXXON RESEARCH ENGINEERING CO (US) | 2000-09-06 | — | — | EP | claimed |
| US-5611915-A | Process for removal of heteroatoms under reducing conditions in supercritical water | EXXON RESEARCH AND ENGINEERING COMPANY (US) | 1997-03-18 | — | — | US | claimed |
| EP-0671454-A2 | Process for removal of heteroatoms | EXXON RESEARCH AND ENGINEERING COMPANY (US) | 1995-09-13 | — | — | EP | claimed |
| CN-115073420-A | Preparation method of 2-phenylbenzothiophene derivative | 陕西维世诺新材料有限公司 | 2022-09-20 | — | — | CN | disclosed |
| CN-110483475-B | Method for preparing benzothiophene compound by silver oxide catalysis method | 绍兴文理学院 | 2020-11-27 | — | — | CN | disclosed |
| CN-110734452-A | semiconductor materials, and preparation method and application thereof | 北京大学深圳研究生院 | 2020-01-31 | — | — | CN | disclosed |
| CN-110483475-A | A kind of method that silver oxide catalysis method prepares benzothiophenes | UNIV SHAOXING | 2019-11-22 | — | — | CN | disclosed |
| US-7163954-B2 | Substituted naphthyl benzothiophene acids | WYETH (US) | 2007-01-16 | — | — | US | disclosed |
| CN-1882561-A | Substituted naphthyl benzothiophene acids | WYETH CORP (US) | 2006-12-20 | — | — | CN | disclosed |
| EP-1664015-A1 | SUBSTITUTED NAPHTHYL BENZOTHIOPHENE ACIDS | Wyeth (US) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005030750-A1 | SUBSTITUTED NAPHTHYL BENZOTHIOPHENE ACIDS | WYETH (US) | 2005-04-07 | — | — | WO | disclosed |
| US-20050070587-A1 | Substituted naphthyl benzothiophene acids | WYETH (US) | 2005-03-31 | — | — | US | disclosed |
| EP-0671454-B1 | Process for removal of heteroatoms | EXXON RESEARCH ENGINEERING CO (US) | 2000-09-06 | — | — | EP | disclosed |
| US-5611915-A | Process for removal of heteroatoms under reducing conditions in supercritical water | EXXON RESEARCH AND ENGINEERING COMPANY (US) | 1997-03-18 | — | — | US | disclosed |
| EP-0671454-A2 | Process for removal of heteroatoms | EXXON RESEARCH AND ENGINEERING COMPANY (US) | 1995-09-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070587-A1 | Substituted naphthyl benzothiophene acids | TST, GNPAT, NUDT1 | APP 3056/4885HSD17B1 618/4885HSD17B2 628/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.