Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | AR | P10275 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.51 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.50 |
| ▸ | TFEB | P19484 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5385330 | 1.00 | KDM4E (0.59) | KDM4EMAPTARGAALMNA | |
| SCHEMBL3823067 | 0.87 | AR (0.52) | KDM4EMAPTARGAALMNA | |
| SCHEMBL5613611 | 0.83 | MAPT (0.49) | KDM4EMAPTGAALMNATDP1 | |
| SCHEMBL28009577 | 0.83 | MAPT (0.49) | KDM4EMAPTGAALMNATDP1 | |
| SCHEMBL10341377 | 0.82 | MAPT (0.58) | KDM4EMAPTTDP1ALDH1A1NPC1 | |
| SCHEMBL10613251 | 0.82 | MAPT (0.58) | KDM4EMAPTTDP1ALDH1A1NPC1 | |
| SCHEMBL2112646 | 0.81 | NFE2L2 (0.63) | ARGAATDP1ALDH1A1NFE2L2 | |
| SCHEMBL3247450 | 0.81 | NFE2L2 (0.63) | ARGAATDP1ALDH1A1NFE2L2 | |
| SCHEMBL1174499 | 0.80 | MAPT (0.73) | KDM4EMAPTLMNAALDH1A1NPC1 | |
| SCHEMBL10466720 | 0.80 | PRMT1 (0.72) | MAPTARGAALMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE49698-E1 | Substituted dihydroquinazolines | AIC246 AG & CO. KG (DE) | 2023-10-17 | — | — | US | disclosed |
| US-RE46791-E1 | Substituted dihydroquinazolines | AICURIS ANTI-INFECTIVE CURES GMBH (DE) | 2018-04-17 | — | — | US | disclosed |
| US-8513255-B2 | Substituted dihydroquinazolines | AiCuris GmbH + Co. KG. (DE) | 2013-08-20 | — | — | US | disclosed |
| US-8343981-B2 | Heterocyclyl-substituted dihydroquinazolines and their use as antiviral agents | AICURIS GMBH & CO. KG (DE) | 2013-01-01 | — | — | US | disclosed |
| US-8314113-B2 | Substituted dihydroquinazolines II | AICURIS GMBH & CO. KG (DE) | 2012-11-20 | — | — | US | disclosed |
| US-20070281953-A1 | Substituted Dihydroquinazolines II | BAYER HEALTHCARE AG (DE) | 2007-12-06 | — | — | US | disclosed |
| US-20070191387-A1 | Substituted dihydroquinazolines | BAYER HEALTHCARE AG (DE) | 2007-08-16 | — | — | US | disclosed |
| US-20070185121-A1 | Heterocyclyl-substituted dihydroquinazolines and their use as antiviral agents | BAYER HEALTHCARE AG (DE) | 2007-08-09 | — | — | US | disclosed |
| US-7196086-B2 | Substituted dihydroquinazolines | BAYER HEALTHCARE AG (DE) | 2007-03-27 | — | — | US | disclosed |
| US-20050065160-A1 | Substituted dihydroquinazolines | BAYER HEALTHCARE AG (DE) | 2005-03-24 | — | — | US | disclosed |
| EP-0628311-B1 | Xanthine-Derivatives as Antidepressants | KYOWA HAKKO KOGYO KK (JP) | 2002-04-24 | — | — | EP | disclosed |
| US-5587378-A | ADMINISTERING A SUBSTITUTED XANTHINE COMPOUND | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1996-12-24 | — | — | US | disclosed |
| US-5543415-A | ADMINISTERING A XANTHINE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1996-08-06 | — | — | US | disclosed |
| US-5484920-A | XANTHINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1996-01-16 | — | — | US | disclosed |
| EP-0628311-A1 | ANTIDEPRESSANT | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-12-14 | — | — | EP | disclosed |
| EP-0590919-A1 | Therapeutic agents for parkinson's disease | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-04-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050065160-A1 | Substituted dihydroquinazolines | TPMT, TYMP, DPYD | KDM4E 3034/4885MAPT 1906/4885AR 4866/4885 |
| US-20070185121-A1 | Heterocyclyl-substituted dihydroquinazolines and their use as antiviral agents | TYMP, RPL35, EIF2AK2 | KDM4E 2609/4885MAPT 2799/4885AR 4881/4885 |
| US-20070281953-A1 | Substituted Dihydroquinazolines II | EIF2AK2, QDPR, IRF3 | KDM4E 2391/4885MAPT 2707/4885AR 4821/4885 |
| US-20070191387-A1 | Substituted dihydroquinazolines | TPMT, TYMP, DPYD | KDM4E 3034/4885MAPT 1906/4885AR 4866/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.