Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.69 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | DAO | P14920 | 1/20 | 0.45 |
| ▸ | GPR84 | Q9NQS5 | 5/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5387930 | 0.82 | GSK3B (1.00) | GSK3BSMN1; SMN2GPR84 | |
| SCHEMBL5386067 | 0.81 | GSK3B (0.51) | GSK3BHCAR2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL5383593 | 0.79 | GSK3B (0.72) | GSK3BHCAR2SMN1; SMN2DAOGPR84 | |
| SCHEMBL5382157 | 0.79 | GSK3B (0.68) | GSK3BHCAR2SMN1; SMN2GPR84 | |
| SCHEMBL5375440 | 0.77 | GSK3B (0.69) | GSK3BHCAR2SMN1; SMN2GPR84BACE1 | |
| SCHEMBL5390578 | 0.76 | GSK3B (0.67) | GSK3BHCAR2SMN1; SMN2DAOGPR84 | |
| SCHEMBL5390685 | 0.73 | GSK3B (1.00) | GSK3BSMN1; SMN2BACE1 | |
| SCHEMBL13611987 | 0.72 | LMNA (0.54) | GSK3BSMN1; SMN2NPC1RAB9A | |
| SCHEMBL5390774 | 0.72 | GSK3B (0.66) | GSK3BSMN1; SMN2NPC1RAB9A | |
| SCHEMBL10838015 | 0.68 | NPC1 (0.49) | GSK3BSMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7256199-B1 | Pyrimidone derivatives | MITSUBISHI CHEMICAL CORPORATION (JP) | 2007-08-14 | — | — | US | disclosed |
| EP-1115721-B1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEM CORP (JP) | 2003-12-10 | — | — | EP | disclosed |
| EP-1115721-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000018758-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2000-04-06 | — | — | WO | disclosed |