Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 6/20 | 0.68 |
| ▸ | AKT1 | P31749 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5375440 | 0.83 | GSK3B (0.69) | GSK3BSMN1; SMN2ALDH1A1KMT2AHCAR2 | |
| SCHEMBL5383593 | 0.83 | GSK3B (0.72) | GSK3BSMN1; SMN2MEN1KMT2AHCAR2 | |
| SCHEMBL5382154 | 0.83 | GSK3B (0.47) | GSK3BPLA2G7IDO1AAK1HCAR2 | |
| SCHEMBL5387930 | 0.81 | GSK3B (1.00) | GSK3BSMN1; SMN2MEN1KMT2AGPR84 | |
| SCHEMBL5386069 | 0.79 | GSK3B (0.69) | GSK3BSMN1; SMN2HCAR2GPR84 | |
| SCHEMBL5390685 | 0.74 | GSK3B (1.00) | GSK3BSMN1; SMN2MEN1KMT2AXDH | |
| SCHEMBL5375238 | 0.72 | GSK3B (0.60) | GSK3BAKT1IDO1 | |
| SCHEMBL5390578 | 0.69 | GSK3B (0.67) | GSK3BSMN1; SMN2MEN1KMT2AHCAR2 | |
| SCHEMBL27111219 | 0.68 | PIK3CA (0.48) | IDO1AAK1 | |
| SCHEMBL5386254 | 0.67 | GSK3B (1.00) | GSK3BAKT1SMN1; SMN2MAPK1GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7256199-B1 | Pyrimidone derivatives | MITSUBISHI CHEMICAL CORPORATION (JP) | 2007-08-14 | — | — | US | disclosed |
| EP-1115721-B1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEM CORP (JP) | 2003-12-10 | — | — | EP | disclosed |
| EP-1115721-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000018758-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2000-04-06 | — | — | WO | disclosed |